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  1. Article

    Open Access

    Fecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism

    Little is known about the association between gut microbiota and intestinal injury under a state of chronic cerebral hypoperfusion (CCH). Here, the effects of gut microbiota and short-chain fatty acids (SCFAs)...

    Shao-Hua Su, Yi-Fang Wu, Qi Lin, Lin Zhang, Da-Peng Wang… in Journal of Neuroinflammation (2022)

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  2. Article

    Open Access

    URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

    Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms ...

    Shao-Hua Su, Yi-Fang Wu, Qi Lin, Da-Peng Wang, Jian Hai in Journal of Neuroinflammation (2019)

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  3. Article

    Open Access

    Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion

    URB597 (URB) has therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuronal death. The present study investigated the protective effects of URB on autopahgy and mitophagy in a CCH...

    Shao-Hua Su, Yi-Fang Wu, Da-Peng Wang, Jian Hai in Cell Death & Disease (2018)

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