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Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

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  1. Article

    Disrupting off-target Cas9 activity in the liver

    Off-target genome editing in the liver can be reduced by using lipid nanoparticles to deliver oligonucleotides that disrupt the secondary structure of single-guide RNAs as well as short interfering RNAs target...

    Sean A. Dilliard, Daniel J. Siegwart in Nature Biomedical Engineering (2022)

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  2. Article

    Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

    Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of medicines that directly reprogramme the central dogma of biology to prevent and treat disease. However, multiple biological barr...

    Sean A. Dilliard, Daniel J. Siegwart in Nature Reviews Materials (2023)

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