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  1. Article

    Disrupting off-target Cas9 activity in the liver

    Off-target genome editing in the liver can be reduced by using lipid nanoparticles to deliver oligonucleotides that disrupt the secondary structure of single-guide RNAs as well as short interfering RNAs target...

    Sean A. Dilliard, Daniel J. Siegwart in Nature Biomedical Engineering (2022)

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