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Article
Open AccessA ν-support vector regression based approach for predicting imputation quality
Decades of genome-wide association studies (GWAS) have accumulated large volumes of genomic data that can potentially be reused to increase statistical power of new studies, but different genoty** platforms ...
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Article
Open AccessA genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder
Lithium is an effective treatment for Bipolar Disorder (BD) and significantly reduces suicide risk, though the molecular basis of lithium's effectiveness is not well understood. We seek to improve our understa...
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Article
Open AccessModeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
Comorbidity of psychiatric and substance use disorders represents a significant complication in the clinical course of both disorders. Bipolar Disorder (BD) is a psychiatric disorder characterized by severe mo...
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Article
Open AccessIn search of causal variants: refining disease association signals using cross-population contrasts
Genome-wide association (GWA) using large numbers of single nucleotide polymorphisms (SNPs) is now a powerful, state-of-the-art approach to map** human disease genes. When a GWA study detects association bet...
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Article
Open AccessGenetic analysis of the maximum drinks phenotype
Using data provided by the Collaborative Study on the Genetics of Alcoholism we studied the genetics of a quantitative trait: the maximum number of drinks consumed in a 24-hour period. A two-stage method was u...
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Article
Open AccessGenetic analysis of maximum cigarette-use phenotypes
Using the Framingham Heart Study data set provided for Genetic Analysis Workshop 13, we defined the cigarette-use phenotype M for smokers to be the maximum number of cigarettes-per-day (MAXCIG) reported over the ...