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  1. No Access

    Article

    Prenatal cannabis exposure, the brain, and psychopathology during early adolescence

    Prenatal cannabis exposure (PCE) is associated with mental health problems in early adolescence, but the possible neurobiological mechanisms remain unknown. In a large longitudinal sample of adolescents (ages ...

    David A. A. Baranger, Alex P. Miller, Aaron J. Gorelik… in Nature Mental Health (2024)

  2. Article

    Open Access

    Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking

    Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to ...

    Emma C. Johnson, Isabelle Austin-Zimmerman, Hayley H. A. Thorpe… in Neuropsychopharmacology (2024)

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  3. No Access

    Article

    Characterizing Alcohol Expectancies in the ABCD Study: Associations with Sociodemographic Factors, the Immediate Social Environment, and Genetic Propensities

    Alcohol expectancies (AEs) are associated with likelihood of alcohol initiation and subsequent alcohol use disorders. It is unclear whether genetic predisposition to alcohol use and/or related traits contribut...

    Emma C. Johnson, Sarah E. Paul, David A. A. Baranger… in Behavior Genetics (2023)

  4. No Access

    Article

    A Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study

    Genetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations are present dur...

    Aaron J. Gorelik, Sarah E. Paul, Nicole R. Karcher, Emma C. Johnson… in Behavior Genetics (2023)

  5. No Access

    Article

    Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

    Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates ...

    Alexander S. Hatoum, Sarah M. C. Colbert, Emma C. Johnson… in Nature Mental Health (2023)

  6. No Access

    Article

    The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates

    Substance use disorders commonly co-occur with one another and with other psychiatric disorders. They share common features including high impulsivity, negative affect, and lower executive function. We tested ...

    Alexander S. Hatoum, Emma C. Johnson, Sarah M. C. Colbert… in Neuropsychopharmacology (2022)