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    Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

    We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells (and o...

    Toshihiro Mineta, Samuel D. Rabkin, Takahito Yazaki, William D. Hunter… in Nature Medicine (1995)