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Article
Efficacy and Safety of Intrathecal Morphine for Cesarean Delivery: A Narrative Review
Pain management is a critical aspect of care during and following a cesarean delivery. Without proper control of pain, individuals can experience poor mobility, increased thromboembolic events, and difficulty ...
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Article
Diabetic Neuropathy: A Guide to Pain Management
Diabetic neuropathy is a common complication of diabetes mellitus (DM) and can affect up to 50% of DM patients during their lifetime. Patients typically present with numbness, tingling, pain, and loss of sensa...
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Article
Evolving Concepts of Pain Management in Elderly Patients
The elderly population typically suffer from a variety of diseases that mostly reflect the degenerative changes linked with the aging process. These diseases may be exacerbated by acute pain or by an abrupt ag...
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Article
Frontiers in Acute Pain Management: Emerging Concepts in Pain Pathways and the Role of VX-548 as a Novel NaV1.8 Inhibitor: A Narrative Review
Despite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of associated adverse effects, including dependence and overdose, as demonstrated throug...
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Article
Open AccessTumor Necrosis Factor and Interleukin Modulators for Pathologic Pain States: A Narrative Review
Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines, specifically tumor necrosis factor (TNF) and interleukins (...
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Article
Assessing Risk Factors and Comorbidities in the Treatment of Chronic Pain: A Narrative Review
Chronic pain affects a significant portion of the population globally, making it a leading cause of disability. Understanding the multifaceted nature of chronic pain, its various types, and the intricate relat...
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Article
Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic Drugs, and Non-Medicinal Methods
The present investigation evaluated integration of novel medication technology to enhance treatment options, while improving patient outcomes in acute pain management. In this regard, we focused on determining...
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Article
Open AccessFake Xanax: Designer Emerging Benzodiazepine Epidemic Linked to Morbidity and Mortality a Narrative Review
Etizolam is a thienodiazepine derivative which produces an anxiolytic effect similar to benzodiazepines such as alprazolam (Xanax). Like classic benzodiazepines, etizolam has a high affinity towards the GABAA rec...
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Article
Systematic Review and Meta-Analysis of the Effectiveness of Radiofrequency Ablation of the Sacroiliac Joint
To evaluate the effectiveness of radiofrequency neurotomy in managing sacroiliac joint pain utilizing a systematic review with meta-analysis of randomized controlled trials (RCTs) and observational studies.
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Article
Peripheral Nerve Stimulation in Postoperative Analgesia: A Narrative Review
Recent research has shown the effectiveness of peripheral nerve stimulators (PNS) in managing chronic pain conditions. Ongoing studies aim to explore its potential application in treating acute postoperative p...
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Article
Neuropsychiatric Effects Associated with Opioid-Based Management for Palliative Care Patients
The abundance of opioids administered in the palliative care setting that was once considered a standard of care is at present necessitating that providers evaluate patients for unintentional and deleterious s...
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Article
Evolving Role of Viltolarsen for Treatment of Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is one of the most prevalent X-linked inherited neuromuscular disorders, with an estimated incidence between 1 in 3500 and 5000 live male births. The median life expectancy at...
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Article
Impulse control disorders in Parkinson’s disease patients treated with pramipexole and ropinirole: a systematic review and meta-analysis
This analysis is the first systematic review and meta-analysis assessing occurrences of ICD in PD patients treated with oral DAs: ropinirole (ROP) and pramipexole (PRX). This study compares the two oral DAs to...
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Article
IPACK Block Efficacy for Acute Pain Management after Total Knee Replacement: A Review
Patients often experience a significant degree of knee pain following total knee replacement (TKR). To alleviate this pain, nerve blocks may be performed such as the adductor canal block (ACB). However, ACBs a...
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Article
Ofatumumab: A Novel Anti-CD20 Monoclonal Antibody for Multiple Sclerosis: A Review of Clinical Considerations
Multiple sclerosis (MS), an autoimmune central nervous system disease responsible for significant morbidity and mortality worldwide, remains imperfectly understood and treated clinically. Recent advances in tr...
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Article
Treatment modalities for infantile spasms: current considerations and evolving strategies in clinical practice
Infantile spasms, newly classified as infantile epileptic spasm syndrome (IESS), occur in children under 2 years of age and present as an occur as brief, symmetrical, contractions of the musculature of the nec...
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Article
Divalproex, Valproate, & Develo** Treatment Options for Cluster Headache Prophylaxis: Clinical Practice Considerations
Regarding the preventive treatment of CH, there are few placebo-controlled studies, meaning most treatment recommendations by physicians are limited to results from open observational studies. Additionally, ex...
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Article
The role of belzutifan, an inhibitor of hypoxia-inducible factor, for renal cell carcinoma in adults with Von Hippel–Lindau disease: a review
Von Hippel–Lindau (VHL) is an autosomal dominant disease that predisposes individuals to various types of malignancies, including renal cell carcinoma, systemic hemangioblastomas, pheochromocytomas, pancreatic...
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Article
Electronic Health Record Recording of Patient Pain: Challenges and Discrepancies
In the present review, various categories of pain, clinician-observed pain scales, and patient-reported pain scales are evaluated to better understand factors that impact patient pain perceptions. Additionally...
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Article
Non-CGRP Antagonist/Non-Triptan Options for Migraine Disease Treatment: Clinical Considerations
Although the association between CGRP and migraine disease is well-known and studied, therapies can target other pathways to minimize migraine symptoms. It is important to understand the role of these medicati...
