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  1. No Access

    Article

    Imaging excised apical plasma membrane patches of MDCK cells in physiological conditions with atomic force microscopy

     We combined the patch-clamp technique with atomic force microscopy (AFM) to visualize plasma membrane proteins protruding from the extracellular surface of cultured kidney cells (MDCK cells). To achieve molec...

    J. Lärmer, S. W. Schneider, T. Danker, A. Schwab, H. Oberleithner in Pflügers Archiv (1997)

  2. No Access

    Article

    Molecular weights of individual proteins correlate with molecular volumes measured by atomic force microscopy

     Proteins are usually identified by their molecular weights, and atomic force microscopy (AFM) produces images of single molecules in three dimensions. We have used AFM to measure the molecular volumes of a nu...

    S. W. Schneider, J. Lärmer, R. M. Henderson, H. Oberleithner in Pflügers Archiv (1998)

  3. No Access

    Article

    ATP-Induced Shape Change of Nuclear Pores Visualized with the Atomic Force Microscope

    Bidirectional transport of molecules between nucleus and cytoplasm through the nuclear pore complexes (NPCs) spanning the nuclear envelope plays a fundamental role in cell function and metabolism. Nuclear imp...

    A., Rakowska, T. Danker, S.W. Schneider, H. Oberleithner in The Journal of Membrane Biology (1998)

  4. No Access

    Article

    Volume dynamics in migrating epithelial cells measured with atomic force microscopy

    Migration of transformed renal epithelial cells (transformed Madin-Darby canine kidney cells, MDCK-F cells) relies on the activity of a Ca2+-sensitive K+ channel (IK channel) that is more active at the rear end o...

    S. W. Schneider, P. Pagel, C. Rotsch, T. Danker, H. Oberleithner… in Pflügers Archiv (2000)

  5. No Access

    Article

    Kiss and Run Mechanism in Exocytosis

    S.W. Schneider in The Journal of Membrane Biology (2001)

  6. No Access

    Article

    Kiss and Run Mechanism in Exocytosis

    S.W. Schneider in The Journal of Membrane Biology (2001)

  7. No Access

    Article

    Secretion Pores in Human Endothelial Cells during Acute Hypoxia

    Weibel-Palade bodies (WPB) are endothelial vesicles that store von Willebrand factor (vWF), involved in the early phase of hemostasis. In the present study we investigated the morphodynamics of single WPB plas...

    T. Goerge, A. Niemeyer, P. Rogge, R. Ossig… in The Journal of Membrane Biology (2002)

  8. No Access

    Article

    Endothelial Cell Swelling by Aldosterone

    There is accumulating evidence that mineralocorticoids not only act on kidney but also on the cardiovascular system. We investigated the response of human umbilical venous endothelial cells (HUVECs) to aldoste...

    H. Oberleithner, S. W. Schneider, L. Albermann… in The Journal of Membrane Biology (2003)

  9. Article

    Open Access

    Mss4 protein is a regulator of stress response and apoptosis

    Mss4 (mammalian suppressor of Sec4) is an evolutionarily highly conserved protein and shows high sequence and structural similarity to nucleotide exchange factors. Although Mss4 tightly binds a series of exocy...

    B M Walter, C Nordhoff, G Varga, G Goncharenko, S W Schneider… in Cell Death & Disease (2012)

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  10. No Access

    Article

    Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity

    Heparanase-1 (HPSE) plays a pivotal role in structural remodeling of the ECM and the glycocalyx, thus conferring protumorigenic, proangiogenic and prometastatic properties to many cancer entities. In addition ...

    Y Yang, C Gorzelanny, A T Bauer, N Halter, D Komljenovic, T Bäuerle, L Borsig… in Oncogene (2015)

  11. Article

    Open Access

    Bladder cancer-derived interleukin-1 converts the vascular endothelium into a pro-inflammatory and pro-coagulatory surface

    Bladder cancer cells orchestrate tumour progression by pro-inflammatory cytokines. Cytokines modulate the local tumour microenvironment and increase the susceptibility of tumour distant tissues for metastasis....

    A. John, C. Günes, C. Bolenz, S. Vidal-y-Sy, A. T. Bauer, S. W. Schneider… in BMC Cancer (2020)

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