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  1. No Access

    Article

    Antinociceptive Effect of Ethowurtzine, a New Compound from the Class of Hexaazaizowurzitane

    Analysis of specific pharmacological activity evaluated high antinociceptive efficacy of the first synthesized compound 10-di(ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,03,11,05,9]do...

    S. G. Krylova, E. A. Kiseleva… in Bulletin of Experimental Biology and Medic… (2022)

  2. No Access

    Article

    Some Aspects of Investigation of the Central Mechanism of Antinociceptive Effect of a New Analgetic from the Hexaazaisowurtzitane Group

    Possible involvement of μ1- and κ-opioid receptors and cannabinoid type 1 receptors (CB1) into the mechanism of analgesic activity of the experimental drug product “Thiowurtzine, (capsule 120 mg)” synthesized on ...

    S. G. Krylova, K. A. Lopatina… in Bulletin of Experimental Biology and Medic… (2021)

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    Article

    Pharmacokinetics of a New Analgesic on the Basis of Hexaazaisowurtzitane Derivative

    We studied pharmacokinetics of a new analgesic based on a hexaazaisowurtzitane derivative (thiowurtzine, TWZ). A method for measuring TWZ in organs and tissues by HPLC/MS/MS was developed and validated. The se...

    O. S. Bryushinina, E. A. Yanovskaya… in Bulletin of Experimental Biology and Medic… (2021)

  4. No Access

    Article

    Analgesic Activity of Hexaazaisowurtzitane Derivatives

    Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,03, 11,05, 9] dodecane (thiowurtzine) was observed in the thermal...

    S. G. Krylova, T. N. Povet’eva, E. P. Zueva… in Bulletin of Experimental Biology and Medic… (2019)

  5. No Access

    Article

    Anti-Ischemic Activity of n-Tyrozol under Conditions of Repeated Transient Myocardial Ischemia in Rats

    We studied anti-ischemic activity of n-tyrozol under conditions of repeated transient myocardial ischemia in rats caused by repeated (5×3 min) occlusion of the left coronary artery. n-Tyrozol administered intrape...

    M. B. Plotnikov, G. A. Chernysheva… in Bulletin of Experimental Biology and Medic… (2018)

  6. No Access

    Article

    A search for raw materials for the isolation of shikimic acid

    The content of shikimic acid in the vegetative parts of a number of plants growing in the Altai Territory has been studied. The greatest content of shikimic acid (about 1.5%) was found in the coniferous needle...

    D. V. Bochkov, S. V. Sysolyatin… in Russian Journal of Bioorganic Chemistry (2013)