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9 Result(s)

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  1. No Access

    Article

    Analysis of Ly49 gene transcripts in mature NK cells supports a role for the Pro1 element in gene activation, not gene expression

    The variegated expression of murine Ly49 loci has been associated with the probabilistic behavior of an upstream promoter active in immature cells, the Pro1 element. However, recent data suggest that Pro1 may be ...

    M V McCullen, H Li, M Cam, S K Sen, D W McVicar, S K Anderson in Genes & Immunity (2016)

  2. No Access

    Article

    Characterization of KIR intermediate promoters reveals four promoter types associated with distinct expression patterns of KIR subtypes

    The human killer cell immunoglobulin-like receptor (KIR) genes contain multiple promoters that control the process of gene activation and variegated expression of KIR on natural killer (NK) and T cells. Specific ...

    H Li, P W Wright, M McCullen, S K Anderson in Genes & Immunity (2016)

  3. No Access

    Article

    Characterization of a weakly expressed KIR2DL1 variant reveals a novel upstream promoter that controls KIR expression

    Members of the human KIR (killer cell immunoglobulin-like receptor) class I major histocompatibility complex receptor gene family contain multiple promoters that determine the variegated expression of KIR on n...

    P W Wright, H Li, A Huehn, G M O'Connor, S Cooley, J S Miller… in Genes & Immunity (2014)

  4. No Access

    Article

    Identification of a KIR antisense lncRNA expressed by progenitor cells

    Human NK cells express cell surface class I MHC receptors (killer cell immunoglobulin-like receptor, KIR) in a probabilistic manner. Previous studies have shown that a distal promoter acts in conjunction with ...

    P W Wright, A Huehn, F Cichocki, H Li, N Sharma, H Dang, T R Lenvik… in Genes & Immunity (2013)

  5. No Access

    Article

    Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome

    The mouse Ly49 and human killer cell immunoglobulin-like receptors (KIR) gene clusters encode activating and inhibitory class I MHC receptors on natural killer (NK) cells. A direct correlation between the presenc...

    S Belanger, L-H Tai, S K Anderson, A P Makrigiannis in Genes & Immunity (2008)

  6. No Access

    Article

    Identification of bidirectional promoters in the human KIR genes

    Although the class I MHC receptors expressed by human and mouse natural killer (NK) cells have distinct molecular origins, they are functional analogues that are expressed in a variegated pattern. The murine L...

    G E Davies, S M Locke, P W Wright, H Li, R J Hanson, J S Miller… in Genes & Immunity (2007)

  7. No Access

    Article

    Identification of distal KIR promoters and transcripts

    A more complete understanding of the transcriptional control of the human and murine class I MHC receptors will help to shed light on the mechanism of selective, stochastic, gene activation that operates in th...

    M J Stulberg, P W Wright, H Dang, R J Hanson, J S Miller, S K Anderson in Genes & Immunity (2007)

  8. No Access

    Article

    Complete elucidation of a minimal class I MHC natural killer cell receptor haplotype

    The BALB/c inbred mouse is widely used in models of infectious disease, transplantation, and cancer. The differences in the immune responses of BALB/c compared to C57BL/6 mice are especially valuable for the iden...

    S K Anderson, K Dewar, M-L Goulet, G Leveque, A P Makrigiannis in Genes & Immunity (2005)

  9. No Access

    Article

    Direct sequence comparison of two divergent class I MHC natural killer cell receptor haplotypes

    The murine Ly49 gene family encoding natural killer cell receptors for class I MHC is an example of a rapidly evolving cluster of immune response genes. Determining the genomic sequence of the 129S6/SvEvTac (129S...

    A P Makrigiannis, D Patel, M-L Goulet, K Dewar, S K Anderson in Genes & Immunity (2005)