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    Implications of Chronobiology for 5-Fluorouracil (5-Fu) Efficacy

    The drug 5-fluorouracil (5-FU) has remained the main active drug against gastrointestinal malignancies. Both its tolerability and/or its efficacy have been increased through combination with folinic acid (FA) ...

    F. Lévi, S. Brienza, G. Metzer… in Novel Approaches to Selective Treatments o… (1993)