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Article
Influence of oxaliplatin on 5-fluorouracil plasma clearance and clinical consequences
The influence of oxaliplatin (OXA) on 5-fluorouracil (5-FU) plasma clearance was investigated. Patients and methods: A group of 29 patients with advanced colorectal cancer refractory to prior weekly 8-h 5-FU inf...
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Chapter
Implications of Chronobiology for 5-Fluorouracil (5-Fu) Efficacy
The drug 5-fluorouracil (5-FU) has remained the main active drug against gastrointestinal malignancies. Both its tolerability and/or its efficacy have been increased through combination with folinic acid (FA) ...
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Chapter
Oxalatoplatinum (I-OHP): Experimental and Clinical Studies
1,2 diamino cychlohexane (trans-I) oxalatoplatinum II was isolated by Kidani among isomeric mixture of DACH derivatives of Platinum as yielding the highest survival increment on L1210 leukemia.
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Chapter and Conference Paper
Intensive and prolonged first line chemotherapy in breast cancer
One hundred and eleven patients presenting a breast cancer were treated with intensive and prolonged chemotherapy from 1980 to 1990. Medium age is 50, 2 patients have less than 20 and 5 more than 70. All fulfi...