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Subsequent treatment for locally advanced non-small-cell lung cancer that progressed after definitive chemoradiotherapy and consolidation therapy with durvalumab: a multicenter retrospective analysis (TOPGAN 2021-02)

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  1. Article

    Open Access

    Second-line immunosuppressant administration for steroid-refractory immune-related adverse events in patients with lung cancer

    Evidence for use of second-line immunosuppressants for immune-related adverse events (irAEs) is inadequate. Therefore, a multicenter analysis should assess the efficacy of second-line immunosuppressants for se...

    Shinsuke Ogusu, Yuhei Harutani, Takehiro Tozuka… in Cancer Immunology, Immunotherapy (2023)

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  2. Article

    Open Access

    Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity

    Approximately 15–30% of patients with lung cancer harbor mutations in the EGFR gene. Major EGFR mutations (>90% of EGFR-mutated lung cancer) are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs). Many un...

    Takahiro Yoshizawa, Ken Uchibori, Mitsugu Araki… in npj Precision Oncology (2021)

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