153 Result(s)

Article

Lnc-HIBADH-4 Regulates Autophagy-Lysosome Pathway in Amyotrophic Lateral Sclerosis by Targeting Cathepsin D

Amyotrophic lateral sclerosis (ALS) is the most prevalent and lethal class of severe motor neuron diseases (MND) with no efficacious treatment. The pathogenic mechanisms underlying ALS remain unclear. Nearly 9...

**gxuan Huang, Yujiao Yu, Dejiang Pang, Chunyu Li, Qianqian Wei… in Molecular Neurobiology (2024)

Article

MIIP downregulates PD-L1 expression through HDAC6 in cutaneous melanoma

Immune checkpoint inhibitors have improved the objective response rate and survival of melanoma patients. However, there are still many melanoma patients suffering from disease progression due to primary or se...

Ting Li, Ruwei **ng, Lijie **ang, Haotian Liu… in Holistic Integrative Oncology (2024)

Article

Multi-view Self-supervised Learning and Multi-scale Feature Fusion for Automatic Speech Recognition

To address the challenges of the poor representation capability and low data utilization rate of end-to-end speech recognition models in deep learning, this study proposes an end-to-end speech recognition mode...

**gyu Zhao, Ruwei Li, Maocun Tian, Weidong An in Neural Processing Letters (2024)

Article

Plasma GFAP as a prognostic biomarker of motor subtype in early Parkinson’s disease

Parkinson’s disease (PD) is a heterogeneous movement disorder with different motor subtypes including tremor dominant (TD), indeterminate and postural instability, and gait disturbance (PIGD) motor subtypes. P...

Ningning Che, Ruwei Ou, Chunyu Li, Lingyu Zhang, Qianqian Wei… in npj Parkinson's Disease (2024)

Article

Author Correction: Plastic waste discharge to the global ocean constrained by seawater observations

Yanxu Zhang, Peipei Wu, Ruochong Xu, Xuantong Wang, Lili Lei… in Nature Communications (2023)

Article

Longitudinal evolution of sleep disturbances in early multiple system atrophy: a 2‐year prospective cohort study

The progression of sleep disturbances remains unclear in patients with early multiple system atrophy (MSA). We aimed to explore the frequency, severity, and coexistence of 2-year longitudinal changes of sleep ...

Lingyu Zhang, Yanbing Hou, Chunyu Li, Qianqian Wei, Ruwei Ou, Kuncheng Liu… in BMC Medicine (2023)

Article

Plasma glial fibrillary acidic protein as a biomarker of disease progression in Parkinson’s disease: a prospective cohort study

Reactive astrogliosis has been demonstrated to have a role in Parkinson’s disease (PD); however, astrocyte-specific plasma glial fibrillary acidic protein (GFAP)’s correlation with PD progression remains unkno...

Junyu Lin, Ruwei Ou, Chunyu Li, Yanbing Hou, Lingyu Zhang, Qianqian Wei… in BMC Medicine (2023)

Article

Modified version of unified multiple system atrophy rating scale for remote video-based assessments

We modified the original Unified Multiple System Atrophy Rating Scale (UMSARS) for remote video-based visits by excluding ocular motor dysfunction, increased tone, and body sway, resulting in a 23-item UMSARS ...

Yi **ao, Lingyu Zhang, Qianqian Wei, Ruwei Ou, Yanbing Hou… in npj Parkinson's Disease (2023)

Article

Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis

Patients with amyotrophic lateral sclerosis (ALS) demonstrate great heterogeneity in the age at onset (AAO), which is closely related to the course of disease. However, most genetic studies focused on the risk...

Chunyu Li, Qianqian Wei, Yanbing Hou, Junyu Lin, Ruwei Ou… in Molecular Neurodegeneration (2023)

Article

Molecular characterization and modulated expression of histone acetyltransferases during cold response of the tick Dermacentor silvarum (Acari: Ixodidae)

Histone acetylation is involved in the regulation of stress responses in multiple organisms. Dermacentor silvarum is an important vector tick species widely distributed in China, and low temperature is a crucial ...

Tingwei Pei, Tianai Zhang, Miao Zhang, Chuks F. Nwanade… in Parasites & Vectors (2023)

Article

Association between peripheral adaptive immune markers and disease progression in Parkinson's disease

The pathogenesis of PD has not been fully elucidated, but recent studies have shown that the adaptive immune system may play a role in the pathology of PD. However, there is a lack of longitudinal studies expl...

Yi **ao, Qianqian Wei, Ruwei Ou, Tianmi Yang, Qirui Jiang… in Journal of Neurology (2023)

Article

Genetic and Phenotypic Spectrum of Amyotrophic Lateral Sclerosis Patients with CCNF Variants from a Large Chinese Cohort

Cyclin F (CCNF) variants have been found to be associated with amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). However, the genetic and clinical characteristics of ALS patients who carry CCNF ...

Bi Zhao, Qirui Jiang, Junyu Lin, Qianqian Wei, Chunyu Li… in Molecular Neurobiology (2023)

Article

The quality of migrant patients’ primary healthcare experiences and patient-centered medical home achievement by community health centers: results from the China greater bay area study

In China, Community Health Centers (CHCs) provide primary healthcare (PHC); however, few studies have examined the quality of PHC services experienced by migrant patients. We examined the potential association...

Yongjun Huo, Xun Kang, Chenyang Zhong… in International Journal for Equity in Health (2023)