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  1. No Access

    Article

    Comprehensive characterization of protein–protein interactions perturbed by disease mutations

    Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein–protein interaction (PPI) networks within human cells. Here, we sh...

    Feixiong Cheng, Junfei Zhao, Yang Wang, Weiqiang Lu, Zehui Liu… in Nature Genetics (2021)

  2. Article

    Open Access

    Cell cycle correlated genes dictate the prognostic power of breast cancer gene lists

    Numerous gene lists or "classifiers" have been derived from global gene expression data that assign breast cancers to good and poor prognosis groups. A remarkable feature of these molecular signatures is that ...

    Jonathan D Mosley, Ruth A Keri in BMC Medical Genomics (2008)

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  3. No Access

    Article

    Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice

    Upregulation of HER2/ErbB2/Neu occurs in 15–30% of human breast cancers and correlates with poor prognosis. Identification of ErbB2/Neu transcriptional targets should facilitate development of novel therapeuti...

    Melissa D Landis, Darcie D Seachrist, Marjorie E Montañez-Wiscovich… in Oncogene (2005)

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    Article

    High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene

    Transgenic (TG) mice expressing the Simian virus 40 T-antigen under the control of the murine inhibin-α promoter (Inhα/Tag) develop granulosa and Leydig cell tumors at the age of 5–6 months, with 100% penetrance....

    Maarit Mikola, Jukka Kero, John H Nilson, Ruth A Keri, Matti Poutanen… in Oncogene (2003)