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  1. No Access

    Article

    Pharmacokinetic–Pharmacodynamic–Efficacy Analysis of Efalizumab in Patients with Moderate to Severe Psoriasis

    Efalizumab is a humanized anti-CD11a monoclonal antibody that demonstrated efficacy in the treatment of patients with psoriasis. The objective of this study was to perform a pharmacokinetic (PK)–pharmacodynami...

    Chee M. Ng, Amita Joshi, Russell L. Dedrick, Marvin R. Garovoy… in Pharmaceutical Research (2005)

  2. No Access

    Article

    Population Pharmacokinetics and Pharmacodynamics of the Anti-CD11a Antibody hu1124 in Human Subjects with Psoriasis

    The pharmacokinetics of hu1124, a human anti-CD11a antibody, were investigated in human subjects with psoriasis. CD11a is a subunit of LFA-1, a cell surface molecule involved in T cell mediated immune response.....

    Robert J. Bauer, Russell L. Dedrick… in Journal of Pharmacokinetics and Biopharmac… (1999)