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    In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

    Drug-induced liver injury (DILI) is not only a major concern for all patients requiring drug therapy, but also for the pharmaceutical industry. Many new in vitro assays and pre-clinical animal models are being...

    Brett A. Howell, Yuching Yang, Rukmini Kumar… in Journal of Pharmacokinetics and Pharmacody… (2012)