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Open AccessU-shaped association between serum calcium and in-hospital mortality in diabetes patients with congestive heart failure: a cohort study
Previous studies have reported that the significant association between serum calcium and mortality substantially in patients, especially among those with intensive care unit (ICU). And In diabetes mellitus, c...
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Article
Open AccessVertical differences in carbon metabolic diversity and dominant flora of soil bacterial communities in farmlands
The carbon cycle in soil is significantly influenced by soil microbes. To investigate the vertical distribution of the dominant groups in agricultural soil and the carbon metabolic diversity of soil bacteria, ...
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Open AccessClinicopathological characteristics and prognosis in patients with monoclonal gammopathy and renal damage in central China: a multicenter retrospective cohort study
Renal involvement is common in monoclonal gammopathy (MG); however, the same patient may have both MG and non-paraprotein-associated renal damage. Accordingly, distinguishing the cause of renal damage is neces...
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Open AccessOverall survival and short-term efficacy analysis of cervical squamous cell carcinoma with skeletal muscle and 18F-FDG PET/CT parameters
2-[18F]fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) can provide tumor biological metabolism and skeletal muscle composition information. The aim of this study was to ...
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Open AccessTemporal dendritic heterogeneity incorporated with spiking neural networks for learning multi-timescale dynamics
It is widely believed the brain-inspired spiking neural networks have the capability of processing temporal information owing to their dynamic attributes. However, how to understand what kind of mechanisms con...
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Open AccessFAT4 expression in peripheral blood mononuclear cells is associated with prognosis and immune cell infiltration in hepatocellular carcinoma
Peripheral blood mononuclear cell (PBMC) genes reflect the host immune status and could be suitable for evaluating the prognosis of patients with hepatocellular carcinoma (HCC), for which a reliable biomarker ...
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Open AccessRewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation
N6-methyladenosine (m6A), one of the most prevalent mRNA modifications in eukaryotes, plays a critical role in modulating both biological and pathological processes. However, it is unknown whether mutant p53 neom...
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Open AccessEffect of social support on anxiety of medical staff one year after COVID-19 outbreak: a moderated mediating model
One year after the outbreak of COVID-19, medical staff are facing high anxiety due to multiple work stresses. Social support has become a protective factor for healthcare workers' anxiety symptoms, but the exa...
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Open AccessApplication of healthcare failure mode and effect analysis in controlling surgical instrument packaging defects
Surgical instrument packaging defects may affect the safety of medical care and patients and waste the hospital workforce, material resources, and financial resources. This study explored the application of he...
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Open AccessMicrofluidic space coding for multiplexed nucleic acid detection via CRISPR-Cas12a and recombinase polymerase amplification
Fast, inexpensive, and multiplexed detection of multiple nucleic acids is of great importance to human health, yet it still represents a significant challenge. Herein, we propose a nucleic acid testing platfor...
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Open AccessPhylogenetic analysis of Arthrospira strains from Ordos based on 16S rRNA
To study the growth rate of different Arthrospira strains, three species of Arthrospira from Ordos alkaline lake, labeled as sp.DD, sp.ER, sp.FB, one species of Arthrospira from Hasu Sea in Hohhot, labeled as sp....
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Open AccessZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes
Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of diabetes, yet how to achieve functional maturation and protect them against metabolic stresses such as glucotoxicity a...
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Open AccessDynamic changes in heparin-binding protein as a prognostic biomarker for 30-day mortality in sepsis patients in the intensive care unit
Heparin-binding protein (HBP) has been shown to be a robust predictor of the progression to organ dysfunction from sepsis, and we hypothesized that dynamic changes in HBP may reflect the severity of sepsis. We...
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Open AccessA database of animal metagenomes
With the rapid development of high-throughput sequencing technology, the amount of metagenomic data (including both 16S and whole-genome sequencing data) in public repositories is increasing exponentially. How...
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Open AccessRNA-seq profiling reveals PBMC RNA as a potential biomarker for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and has extremely high morbidity and mortality. Although many existing studies have focused on the identification of biomarkers, little...
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Open AccessModeling porosity loss in Fe0-based permeable reactive barriers with Faraday’s law
Solid iron corrosion products (FeCPs), continuously generated from iron corrosion in Fe0-based permeable reactive barriers (PRB) at pH > 4.5, can lead to significant porosity loss and possibility of system’s fail...
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Open AccessMetagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus
Varicella Zoster Virus (VZV) is endemic worldwide, causing varicella in children and zoster upon reactivation in adults. This study concerned a metagenomic analysis of a throat swab sample collected in China, ...
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Open AccessDeep generative neural network for accurate drug response imputation
Drug response differs substantially in cancer patients due to inter- and intra-tumor heterogeneity. Particularly, transcriptome context, especially tumor microenvironment, has been shown playing a significant ...
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Open AccessCharacterizing the impact of pyrite addition on the efficiency of Fe0/H2O systems
The role of pyrite (FeS2) in the process of water treatment using metallic iron (Fe0) was investigated. FeS2 was used as a pH-shifting agent while methylene blue (MB) and methyl orange (MO) were used as an indica...
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Open AccessImmune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the comprehensive understanding of the immune landscape of the tumor microenvironment (TME). Here, we obtain a detailed immune...