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Article
Giant pyroelectricity in nanomembranes
Pyroelectricity describes the generation of electricity by temporal temperature change in polar materials1–3. When free-standing pyroelectric materials approach the 2D crystalline limit, how pyroelectricity behav...
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Article
Structural basis for the tethered peptide activation of adhesion GPCRs
Adhesion G-protein-coupled receptors (aGPCRs) are important for organogenesis, neurodevelopment, reproduction and other processes1–6. Many aGPCRs are activated by a conserved internal (tethered) agonist sequence ...
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Article
Open AccessStructural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2
Arrestins recognize different receptor phosphorylation patterns and convert this information to selective arrestin functions to expand the functional diversity of the G protein-coupled receptor (GPCR) superfam...
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Article
Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex
Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited knowledge of their ligand regulation or structure is available1–3. Here we report that glucocorticoid stress hormones activate...
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Article
Open AccessPrimary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche formation are poorly understoo...
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Article
Open AccessA region-resolved mucosa proteome of the human stomach
The human gastric mucosa is the most active layer of the stomach wall, involved in food digestion, metabolic processes and gastric carcinogenesis. Anatomically, the human stomach is divided into seven regions,...
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Article
Open AccessSlMYB12 Regulates Flavonol Synthesis in Three Different Cherry Tomato Varieties
Cherry tomato (Lycopersicon esculentum M.) is considered a healthy fruit worldwide due to its wide range of nutrients. Flavonol, one of the major nutrients in cherry tomato, has antioxidant and cell-modulating pr...
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Article
Open AccessMitigation of a nitrate reducing Pseudomonas aeruginosa biofilm and anaerobic biocorrosion using ciprofloxacin enhanced by D-tyrosine
Pseudomonas aeruginosa (PA) is a ubiquitous microbe. It can form recalcitrant biofilms in clinical and industrial settings. PA biofilms cause infections in patients. They also cause bioco...
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Article
Open AccessNo effect of Bt Cry1Ie toxin on bacterial diversity in the midgut of the Chinese honey bees, Apis cerana cerana (Hymenoptera, Apidae)
Cry1Ie protein derived from Bacillus thuringiensis (Bt) has been proposed as a promising candidate for the development of a new Bt-maize variety to control maize pests in China. We studied the response of the mid...
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Article
Open AccessAldosterone induces rapid sodium intake by a nongenomic mechanism in the nucleus tractus solitarius
The purpose of this study was to determine whether aldosterone has a rapid action in the nucleus tractus solitarius (NTS) that increases sodium intake, and to examine whether this effect of aldosterone, if pre...
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Article
Open AccessThree-dimensional Contrast-enhanced Ultrasound in Response Assessment for Breast Cancer: A Comparison with Dynamic Contrast-enhanced Magnetic Resonance Imaging and Pathology
To compare the capabilities of three-dimensional contrast enhanced ultrasound (3D-CEUS) and dynamic contrast-enhanced magnetic resonance (DCE-MRI) in predicting the response to neoadjuvant chemotherapy (NAC) a...
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Article
Open AccessThe effects of Bt Cry1Ie toxin on bacterial diversity in the midgut of Apis mellifera ligustica (Hymenoptera: Apidae)
The honey bee has been regarded as a key species in the environmental risk assessment of biotech crops. Here, the potential adverse effects of Cry1Ie toxin on the midgut bacteria of the worker bees (Apis mellifer...
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Article
Open AccessHistidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration
The formation of glial scar impedes the neurogenesis and neural functional recovery following cerebral ischemia. Histamine showed neuroprotection at early stage after cerebral ischemia, however, its long-term ...
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Article
Open AccessEarly treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion
Subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion develops with progressive white matter and cognitive impairments, yet no effective therapy is available. We investigated t...
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Article
Structural basis for site-specific ribose methylation by box C/D RNA protein complexes
Some RNAs, called guide RNAs, use their encoded sequence information to help direct a protein to where it is required. One of these RNA-protein (RNP) complexes, known as the box C/D RNP, catalyses the site-spe...
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Article
Dieldrin and endrin removal from water by triolein-embedded adsorbent
A novel triolein-embedded adsorbent for removal of persistent organic pollutants (POPs) from water was developed. In this paper, taking dieldrin and endrin as the target pollutants, different factors (temperat...
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Article
Characterization and adsorption behavior of a novel triolein-embedded activated carbon composite adsorbent
A novel triolein-embedded activated carbon composite adsorbent was developed. Experiments were carried out in areas such as the preparation method, the characterization of physicochemical properties, and the a...