40 Result(s)
within
Ru-**a Zhao
Biomedicine
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Article
FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of public health concerns. The activation of FXR shows promise to co...
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Article
Open AccessFluoride impairs vascular smooth muscle A7R5 cell lines via disrupting amino acids metabolism
Given the insidious and high-fatality nature of cardiovascular diseases (CVDs), the emergence of fluoride as a newly identified risk factor demands serious consideration alongside traditional risk factors. Whi...
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Article
Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations
Histone deacetylase inhibitors (HDACis) are important drugs for cancer therapy, but the indistinct resistant mechanisms of solid tumor therapy greatly limit their clinical application. In this study we conduct...
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Article
KLK7, KLK10, and KLK11 in Papillary Thyroid Cancer: Bioinformatic Analysis and Experimental Validation
Despite many studies on papillary thyroid carcinoma (PTC) in the past few decades, some critical and significant genes remain undiscovered. To explore genes that may play crucial roles in PTC, a detailed anal...
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Article
Open AccessMetagenomic characterization of a novel non-ammonia-oxidizing Thaumarchaeota from hadal sediment
The hadal sediment, found at an ocean depth of more than 6000 m, is geographically isolated and under extremely high hydrostatic pressure, resulting in a unique ecosystem. Thaumarchaeota are ubiquitous marine ...
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Article
A phase III randomized, double-blind, placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk
The current study evaluated the efficacy and safety of a denosumab biosimilar, QL1206 (60 mg), compared to placebo in postmenopausal Chinese women with osteoporosis and high fracture risk. At 31 study centers ...
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Immunotherapy and Pain
Immunotherapy was initially developed as a method to treat cancer through the use of the host’s immune system. Now, immunotherapy is used as a treatment for a wide variety of diseases. The connection between t...
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Article
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia
Our previous study showed that H3 receptor antagonists reduced neuronal apoptosis and cerebral infarction in the acute stage after cerebral ischemia, but through an action independent of activation of histaminerg...
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Article
Emerging Role of PD-1 in the Central Nervous System and Brain Diseases
Programmed cell death protein 1 (PD-1) is an immune checkpoint modulator and a major target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated remarkable efficacy in cancer treatment. Accumu...
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Article
Open AccessMultivariable clinical-genetic model for predicting dyskinesia in early-onset Parkinson’s disease
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Article
Genetic Analysis of Prosaposin, the Lysosomal Storage Disorder Gene in Parkinson’s Disease
Recent genetic studies clearly indicate that variants in several lysosomal genes act as risk factors for idiopathic Parkinson’s disease (PD). Variants in the co-activator of glucocerebrosidase gene (GBA) and the ...
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Article
Correction to: Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis
In the original version of this article, unfortunately the Fig. 3C and 3F were published with incorrect version. The correct version of the Fig. 3C and 3F are given below. This has been corrected by publishing...
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Article
Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis
28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffe...
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Article
Elevated ROS depress mitochondrial oxygen utilization efficiency in cardiomyocytes during acute hypoxia
Mitochondria are important sites for the production of ATP and the generation of ROS in cells. However, whether acute hypoxia increases ROS generation in cells or affects ATP production remains unclear, and th...
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Article
Novel ACADVL variants resulting in mitochondrial defects in long-chain acyl-CoA dehydrogenase deficiency
The pathogenesis of very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is highly heterogeneous and still unclear. Additional novel variants have been recently detected in the population. The molecular a...
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Article
Open AccessIdentification of NEO1 as a prognostic biomarker and its effects on the progression of colorectal cancer
Due to the high morbidity and poor clinical outcomes, early predictive and prognostic biomarker identification is desiderated in colorectal cancer (CRC). As a homologue of the Deleted in Colorectal Cancer (DCC...
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Article
Emerging relationship between RNA helicases and autophagy
RNA helicases, the largest family of proteins that participate in RNA metabolism, stabilize the intracellular environment through various processes, such as translation and pre-RNA splicing. These proteins are...
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Article
Open Accessm6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling
BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive.
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Article
Physiologically based pharmacokinetic–pharmacodynamic modeling for prediction of vonoprazan pharmacokinetics and its inhibition on gastric acid secretion following intravenous/oral administration to rats, dogs and humans
Vonoprazan is characterized as having a long-lasting antisecretory effect on gastric acid. In this study we developed a physiologically based pharmacokinetic (PBPK)-pharmacodynamic (PD) model linking to stomac...
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Article
Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes
Patients with diabetes mellitus have a higher risk of develo** Parkinson’s disease (PD). However, the molecular links between PD and diabetes remain unclear. In this study, we investigated the roles of thior...
