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Article
Exploring the binding pocket for pyridopyrimidine ligands at the CCK1 receptor by molecular docking
Pyridopyrimidine-based analogues are among the most highly potent and selective antagonists of cholecystokinin receptor subtype-1 (CCK1R) described to date. To better understand the structural and chemical fea...
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Article
Studies on the synthesis of β-keto esters derived from dipeptides: search for a low-epimerizing method
β-Keto esters derived from dipeptides areprepared by application of common methodologiesemployed for the synthesis of amino acid-derivedβ-keto esters; however, epimerization of theC-terminal residue occurred t...
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Article
Similarity Study on Peptide γ-turn Conformation Mimetics
The ability of a series of structures to mimic the geometric and electronic properties of an ideal γ–turn has been studied. Initially, an exhaustive conformational analysis was carried out using the molecular ...
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Article
Constrained C-terminal hexapeptide neurotensin analogues containing a 3-oxoindolizidine skeleton
In order to enforce different spatial orientations in the C-terminal hexapeptide of neurotensin (NT8−13) and to gain information about the importance of the 10–11 peptide bond for binding to NT receptors, the Pro