5 Result(s)
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Article
Open AccessThe emerging roles of miRNA-mediated autophagy in ovarian cancer
Ovarian cancer is one of the common tumors of the female reproductive organs. It has a high mortality rate, is highly heterogeneous, and early detection and primary prevention are very complex. Autophagy is a ...
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Article
Open AccessA live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems
The differentiation of pluripotent stem cells (PSCs) into diverse functional cell types provides a promising solution to support drug discovery, disease modeling, and regenerative medicine. However, functional...
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Article
Open AccessThe metabolic flexibility of quiescent CSC: implications for chemotherapy resistance
Quiescence has been observed in stem cells (SCs), including adult SCs and cancer SCs (CSCs). Conventional chemotherapies mostly target proliferating cancer cells, while the quiescent state favors CSCs escape t...
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Article
Open AccessSuppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma
Steroid 5α-reductase type I (SRD5A1) is a validated oncogene in many sex hormone-related cancers, but its role in multiple myeloma (MM) remains unknown. Based on gene expression profiling (GEP) of sequential M...
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Article
Open AccessMicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression
MicroRNAs (miRNAs) have been demonstrated to modulate cellular processes in the liver. However, the role of miRNAs in liver fibrosis is poorly understood. Because the activation of hepatic stellate cells (HSCs...
