21 Result(s)

Reference Work Entry In depth

Chronic Obstructive Pulmonary Disease and Lung Cancer

Juhayna Kassem Davis, Ronald G. Crystal in Encyclopedia of Cancer (2017)

Living Reference Work Entry In depth

Chronic Obstructive Pulmonary Disease and Lung Cancer

Juhayna Kassem Davis, Ronald G. Crystal in Encyclopedia of Cancer

Article

Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia

In Friedreich's ataxia, caused by mutation of the gene encoding the mitochondrial protein frataxin, the major cause of mortality is heart failure. Using mice lacking frataxin in the heart, Hélène Puccio and he...

Morgane Perdomini, Brahim Belbellaa, Laurent Monassier… in Nature Medicine (2014)

Article

Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD

Accelerated lung function decline is a key COPD phenotype; however, its genetic control remains largely unknown. We performed a genome-wide association study using the Illumina Human660W-Quad v.1_A BeadChip. G...

Nadia N. Hansel, Ingo Ruczinski, Nicholas Rafaels, Don D. Sin… in Human Genetics (2013)

Reference Work Entry In depth

Chronic Obstructive Pulmonary Disease and Lung Cancer

Juhayna Kassem, Ronald G. Crystal in Encyclopedia of Cancer (2009)

Article

Modification of gene expression of the small airway epithelium in response to cigarette smoking

The earliest morphologic evidence of changes in the airways associated with chronic cigarette smoking is in the small airways. To help understand how smoking modifies small airway structure and function, we de...

Ben-Gary Harvey, Adriana Heguy, Philip L. Leopold… in Journal of Molecular Medicine (2007)

Article

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4⁺ hemangiocytes

The mechanisms through which hematopoietic cytokines accelerate revascularization are unknown. Here, we show that the magnitude of cytokine-mediated release of SDF-1 from platelets and the recruitment of nonen...

David K **, Koji Shido, Hans-Georg Kopp, Isabelle Petit… in Nature Medicine (2006)

Article

Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking

Cigarette smoking is the leading cause of the respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). While the pathogenesis of COPD is complex, there is abundant evidence that...

Adriana Heguy, Timothy P. O’Connor, Karsta Luettich… in Journal of Molecular Medicine (2006)

Article

Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency

X-linked immunodeficiency with hyper-IgM (HIGM1), characterized by failure of immunoglobulin isotype switching, is caused by mutations of the CD40 ligand (CD40L), which is normally expressed on activated CD4⁺ T c...

Minoru Tahara, Robert G Pergolizzi, Hiroyasu Kobayashi, Anja Krause… in Nature Medicine (2004)

Article

Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis

The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine-mediated interactions of megakaryocyte progenitors with sinusoidal bone marrow end...

Scott T Avecilla, Koichi Hattori, Beate Heissig, Rafael Tejada… in Nature Medicine (2004)

Article

Sampling-Dependent Up-regulation of Gene Expression in Sequential Samples of Human Airway Epithelial Cells

As part of a study of in vivo gene expression levels in the human airway epithelium in response to chronic cigarette smoking, we have identified a number of genes whose expression levels are altered in a time-...

Adriana Heguy, Ben-Gary Harvey, Timothy P O’Connor, Neil R Hackett… in Molecular Medicine (2003)

Article

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1⁺ stem cells from bone-marrow microenvironment

The mechanism by which angiogenic factors recruit bone marrow (BM)-derived quiescent endothelial and hematopoietic stem cells (HSCs) is not known. Here, we report that functional vascular endothelial growth fa...

Koichi Hattori, Beate Heissig, Yan Wu, Sergio Dias, Rafael Tejada… in Nature Medicine (2002)

Article

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

The role of bone marrow (BM)-derived precursor cells in tumor angiogenesis is not known. We demonstrate here that tumor angiogenesis is associated with recruitment of hematopoietic and circulating endothelial ...

David Lyden, Koichi Hattori, Sergio Dias, Carla Costa, Pamela Blaikie… in Nature Medicine (2001)

Article

Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4⁺ T cells

We have investigated whether dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can trigger B cells to produce antigen-specific antibodies without CD4⁺ T-cell help. Dendritic cell...

Toshiaki Kikuchi, Stefan Worgall, Ravi Singh, Malcolm A.S. Moore… in Nature Medicine (2000)

Article

Managed care for viruses

The finding of a common receptor for coxsackievirus and adenovirus should help improve strategies for drug design and gene therapy.

Ronald G. Crystal in Nature Medicine (1997)

Article

IL-6 release and airway administration of human CFTR cDNA adenovirus vector

Noel G. McElvaney, Ronald G. Crystal in Nature Medicine (1995)

Article

The gene as the drug

Caplen et al. (pages 39–46) demonstrate that it is feasible to use liposomes to transfer a human gene in vivo. Can this vector mimic the ability of viruses to effectively transfer genetic information into target ...

Ronald G. Crystal in Nature Medicine (1995)