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  1. Article

    Open Access

    Copy number variations in the genome of the Qatari population

    The populations of the Arabian Peninsula remain the least represented in public genetic databases, both in terms of single nucleotide variants and of larger genomic mutations. We present the first high-resolut...

    Khalid A. Fakhro, Noha A. Yousri, Juan L. Rodriguez-Flores, Amal Robay… in BMC Genomics (2015)

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  2. No Access

    Article

    Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells

    The human airway epithelium is a pseudostratified heterogenous layer comprised of ciliated, secretory, intermediate, and basal cells. As the stem/progenitor population of the airway epithelium, airway basal ce...

    Giacomo Curradi, Matthew S. Walters, Bi-Sen Ding… in Cellular and Molecular Life Sciences (2012)

  3. Article

    Open Access

    Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations

    Populations of the Arabian Peninsula have a complex genetic structure that reflects waves of migrations including the earliest human migrations from Africa and eastern Asia, migrations along ancient civilizati...

    Larsson Omberg, Jacqueline Salit, Neil Hackett, Jennifer Fuller… in BMC Genetics (2012)

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  4. Article

    Open Access

    RNA-Seq quantification of the human small airway epithelium transcriptome

    The small airway epithelium (SAE), the cell population that covers the human airway surface from the 6th generation of airway branching to the alveoli, is the major site of lung disease caused by smoking. The foc...

    Neil R Hackett, Marcus W Butler, Renat Shaykhiev, Jacqueline Salit… in BMC Genomics (2012)

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  5. No Access

    Article

    Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

    The apical junctional complex (AJC), composed of tight and adherens junctions, maintains epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking...

    Renat Shaykhiev, Fouad Otaki, Prince Bonsu… in Cellular and Molecular Life Sciences (2011)

  6. Article

    Open Access

    Quality control in microarray assessment of gene expression in human airway epithelium

    Microarray technology provides a powerful tool for defining gene expression profiles of airway epithelium that lend insight into the pathogenesis of human airway disorders. The focus of this study was to estab...

    Tina Raman, Timothy P O'Connor, Neil R Hackett, Wei Wang, Ben-Gary Harvey… in BMC Genomics (2009)

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  7. No Access

    Article

    A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

    TGF-β mediates epithelial-mesenchymal transitions (EMT) during tumorigenesis but the molecular mechanisms driving this effect have been unclear. The transcriptional repressor SNAIL1 and the downstream effector...

    Theresa Vincent, Etienne P. A. Neve, Jill R. Johnson… in Nature Cell Biology (2009)

  8. No Access

    Article

    Fooling Mother Nature

    Correcting defective genes at the mRNA level shows promise for the treatment of cystic fibrosis.

    Ronald G. Crystal in Nature Biotechnology (2002)

  9. No Access

    Article

    The body as a manufacturer of endostatin

    Ronald G. Crystal in Nature Biotechnology (1999)

  10. No Access

    Article

    Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA

    This study was designed to evaluate the hypothesis that administration of a replication-deficient, recombinant adenovirus vector to the epithelial surface of the respiratory tract can be used to deliver a reco...

    Salvatore J. Cannizzo, Beat M. Frey, Shahin Raffi… in Nature Biotechnology (1997)

  11. No Access

    Article

    Recombinant Proteins of Therapeutic Interest Expressed by Lymphoid Cell Lines Derived from Transgenic Mice

    As a new approach to produce human proteins of therapeutic interest we have derived lymphoid cell lines expressing such proteins from transgenic mice, either by generating trans-hybridomas by cell fusion in vitro

    Andrea Pavirani, Tim Skern, Marianne Le Meur, Yves Lutz, Richard Lathe… in Bio/Technology (1989)