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  1. No Access

    Article

    Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells

    The human airway epithelium is a pseudostratified heterogenous layer comprised of ciliated, secretory, intermediate, and basal cells. As the stem/progenitor population of the airway epithelium, airway basal ce...

    Giacomo Curradi, Matthew S. Walters, Bi-Sen Ding… in Cellular and Molecular Life Sciences (2012)

  2. No Access

    Article

    Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo

    The apical junctional complex (AJC), composed of tight and adherens junctions, maintains epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking...

    Renat Shaykhiev, Fouad Otaki, Prince Bonsu… in Cellular and Molecular Life Sciences (2011)

  3. No Access

    Article

    Fooling Mother Nature

    Correcting defective genes at the mRNA level shows promise for the treatment of cystic fibrosis.

    Ronald G. Crystal in Nature Biotechnology (2002)

  4. No Access

    Article

    The body as a manufacturer of endostatin

    Ronald G. Crystal in Nature Biotechnology (1999)

  5. No Access

    Article

    Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA

    This study was designed to evaluate the hypothesis that administration of a replication-deficient, recombinant adenovirus vector to the epithelial surface of the respiratory tract can be used to deliver a reco...

    Salvatore J. Cannizzo, Beat M. Frey, Shahin Raffi… in Nature Biotechnology (1997)

  6. No Access

    Article

    Recombinant Proteins of Therapeutic Interest Expressed by Lymphoid Cell Lines Derived from Transgenic Mice

    As a new approach to produce human proteins of therapeutic interest we have derived lymphoid cell lines expressing such proteins from transgenic mice, either by generating trans-hybridomas by cell fusion in vitro

    Andrea Pavirani, Tim Skern, Marianne Le Meur, Yves Lutz, Richard Lathe… in Bio/Technology (1989)