Page
%P
7 Result(s)
within
Rohan Shah
Biomedicine
-
Article
Open AccessA pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1
HIV-1 infection remains a major public health concern despite effective combination antiretroviral therapy (cART). The virus enters the central nervous system (CNS) early in infection and continues to cause HI...
-
Book
-
Chapter
Composition and Structure
Lipid nanoparticles, including solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), lipid-drug conjugates (LDC) and polymer-lipid hybrid nanoparticles (PLN), are colloidal carriers with a lipi...
-
Chapter
Introduction
Highly potent, but poorly water-soluble, drug candidates are common outcomes of lead optimization and other such drug discovery programmes. Poor drug solubility presents several challenges including reduced bi...
-
Chapter
Characterization
Lipid nanoparticles are known to present three features—a solid nature, lipid matrix and colloidal (or smaller) particle size. These features are theorized to impart controlled drug release, biocompatibility a...
-
Chapter
Production Techniques
Besides composition and structure, an important factor which influences the performance and characteristics of lipid nanoparticles is their production method, and a variety of production techniques have been i...
-
Chapter
Physicochemical Stability
Recent advances in lipid nanoparticle research suggest that colloidal carriers have great potential for administration of drug molecules. The use of physiological lipids in their matrices presents the advantag...
