9 Result(s)
within
Robert L Martuza
English
Neurology
-
Article
Open AccessCharacterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma
Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal components in many types of cancer. CAFs contribute to hallmarks of cancer such as proliferation, invasion and immu...
-
Article
Single agent efficacy of the VEGFR kinase inhibitor axitinib in preclinical models of glioblastoma
Anti-angiogenic therapy is a promising therapeutic strategy for the highly vascular and malignant brain tumor, glioblastoma (GBM), although current clinical trials have failed to demonstrate an extension in ov...
-
Article
Open AccessIdentification of diagnostic serum protein profiles of glioblastoma patients
Diagnosis of a glioblastoma (GBM) is triggered by the onset of symptoms and is based on cerebral imaging and histological examination. Serum-based biomarkers may support detection of GBM. Here, we explored ser...
-
Article
The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma
Purpose Temozolomide (TMZ), given concurrently with radiotherapy (RT) and as adjuvant monotherapy afterwards, has led to improved survival in glioblastoma multiforme (GBM). However, it is unclear whether its prim...
-
Article
Craniofacial Hemangiopericytoma Associated with Oncogenic Osteomalacia: Case Report
A craniofacial hemangiopericytoma associated with oncogenic osteomalacia is described and the literature is reviewed. A 46 year-old male with multiple fractures and hypophosphatemia was found to have a craniof...
-
Article
Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470
Meningiomas are relatively common (22%) vascular brain tumors. 3–11% of meningiomas are malignant, and defy currently available therapy. Inhibition of neovascularization is one potential strategy for treating ...
-
Article
Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse
To develop a reproducible in vivo model for the growth of human acoustic neuromas and neurofibromas, we implanted tumor specimens (6 acoustic neuromas; 4 neurofibromas; 3 schwannomas arising in skin and soft tiss...
-
Chapter
Genetic Alterations of Nervous System Tumors
The last decade has witnessed revolutionary advances in our understanding of the basic molecular changes associated with carcinogenesis in general and with nervous system tumorigenesis in particular. This repo...
-
Article
Photodynamic therapy is potentiated by Co60 and intratumoral injection of hematoporphyrin derivative
Hematoporphyrin derivative injected directly into a subcutaneous rat glioma resulted in a significant greater tumor growth inhibition than hematoporphyrin derivative injected parenterally upon stimulation by l...
