5 Result(s)
within
Robert L Martuza
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessMyc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
PARP inhibitors (PARPis) have clinical efficacy in BRCA-deficient cancers, but not BRCA-intact tumors, including glioblastoma (GBM). We show that MYC or MYCN amplification in patient-derived glioblastoma stem-lik...
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Article
Open AccessGenetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy
Intratumoural heterogeneity underlies tumour escape from molecularly targeted therapy in glioblastoma. A cell-based model preserving the evolving molecular profiles of a tumour during treatment is key to under...
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Article
Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma
A single sentence summarizing your paper (websum), which will appear online on the table of contents and in e-alerts, has been provided below. Please check this sentence for accuracy and appropriate emphasis.
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Article
Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22
Bilateral acoustic neurofibromatosis (BANF) is a severe autosomal dominant disorder involving development of multiple tumours of the nervous system including meningiomas, gliomas, neurofibromas and particular...
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Article
Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma
The application of recombinant DNA techniques has identified two fundamental mechanisms of tumorigenesis in man. The first involves a qualitative or quantitative change in an oncogene (see ref. 1 for review). ...
