12 Result(s)
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Article
Open AccessDissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk
Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but the complex relationship and the potential pathway are not fully understood.
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Article
Open AccessGenetic risk scores may compound rather than solve the issue of prostate cancer overdiagnosis
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Article
Open AccessPhenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank
Associations between colorectal cancer (CRC) and other health outcomes have been reported, but these may be subject to biases, or due to limitations of observational studies.
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Open AccessLack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis
Epidemiological studies of the relationship between gallstone disease and circulating levels of bilirubin with risk of develo** colorectal cancer (CRC) have been inconsistent. To address possible confounding...
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Article
Open AccessGenetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study
We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorectal cancer risk and to understand the contributions of effects mediated through chan...
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Open AccessSearching for causal relationships of glioma: a phenome-wide Mendelian randomisation study
The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma...
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Open AccessInfluence of obesity-related risk factors in the aetiology of glioma
Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation fram...
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Open AccessUndefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes
Although family history is a major risk factor for colorectal cancer (CRC) a genetic diagnosis cannot be obtained in over 50 % of familial cases when screened for known CRC cancer susceptibility genes. The gen...
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Article
Open AccessMendelian randomisation analysis strongly implicates adiposity with risk of develo** colorectal cancer
Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a...
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Open AccessErratum: Polygenic susceptibility to testicular cancer: implications for personalised health care
Correction to: British Journal of Cancer (2015) 113, 1512–1518. doi:10.1038/bjc.2015.334; published online 13 October 2015 Updated online 26 May 2016: This article was originally published under a CC BY-NC-SA ...
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Article
Open AccessPolygenic susceptibility to testicular cancer: implications for personalised health care
The increasing incidence of testicular germ cell tumour (TGCT) combined with its strong heritable basis suggests that stratified screening for the early detection of TGCT may be clinically useful. We modelled ...
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Article
Erratum to: Survey of familial glioma and role of germline p16 INK4A /p14 ARF and p53 mutation
