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Richard M. **
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Article
Open AccessA randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults
In preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose primaquine we assessed the tolerability, safety, and potenti...
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Open AccessAndrogen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy
Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the vast majority (80–90...
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Surgical technique: proximal extension of instrumentation using sublaminar bands for salvage of postoperative proximal junctional failure in pediatric patients
Proximal junctional failure is a complication that can occur following posterior spine surgery with instrumentation. The ability to surgically revise this complication is important for the spine surgeon, yet t...
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The effect of surgical time on perioperative complications in adolescent idiopathic scoliosis cases. A propensity score analysis
Posterior spinal instrumentation and fusion (PSIF) for adolescent idiopathic scoliosis (AIS) can be lengthy and complication-ridden. The aim of this study was to evaluate the effect of surgical time on periope...
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Multiomic profiling of transcription factor binding and function in human brain
Transcription factors (TFs) orchestrate gene expression programs crucial for brain function, but we lack detailed information about TF binding in human brain tissue. We generated a multiomic resource (ChIP–seq...
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Open AccessMolecular ontogeny underlies the benefit of adding venetoclax to hypomethylating agents in newly diagnosed AML patients
The clinical impact of molecular ontogeny in acute myeloid leukemia (AML) was defined in patients treated with intensive chemotherapy. In a cohort of 314 newly diagnosed AML patients, we evaluated whether mole...
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Open AccessFunction estimation: Quantifying individual differences of hand-drawn functions
Graphical perception is an important part of the scientific endeavour, and the interpretation of graphical information is increasingly important among educated consumers of popular media, who are often present...
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Open Access3D architecture and complex behavior along the simple central San Andreas fault
The central San Andreas Fault (CSAF) exhibits a simple linear large-scale fault geometry, yet seismic and aseismic deformation features vary in a complex way along the fault. Here we investigate fault zone beh...
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Open AccessFrequency and Severity of Hypoglycemia Under Conditions of Increased Hypoglycemic Risk with Insulin Efsitora Alfa Versus Insulin Glargine Treatment in Participants with Type 2 Diabetes
Insulin efsitora alfa (efsitora) is a basal insulin with a flat pharmacokinetic profile and long half-life, enabling weekly dosing. These attributes may provide stable glucose levels. This exploratory phase 1 ...
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Open AccessThe single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of th...
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An evaluation of the utilisation of biosimilar monoclonal antibody drugs in Ireland and barriers to their usage
While biologic drugs have demonstrated efficacy across a range of indications, patient access to these drugs is constrained due to their high cost. Biosimilars provide a means to increase patient access while ...
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Validation of a molecular sex marker in three sturgeons from eastern North America
Despite the importance of sex-specific information for sturgeon conservation and management, sex identification has been a major challenge outside of mature adults on spawning grounds. Recent work identified a...
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Effect of Repeated Reading on Reading Fluency for Adults with Specific Learning Disabilities
The current study implemented an alternating-treatments design with Standard Celeration Charting. The applied experiment occurred via telecommunication and assessed the effectiveness of repeated reading (RR) o...
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Ants vs crabs: competition over seeds on a tropical island ecosystem
Seed dispersal by ants plays a major role globally in plant dynamics for many angiosperms and can be influenced by multiple factors. One of those factors is competition between ants and other organisms for gai...
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Post-election responsibilities for public health in the Democratic Republic of the Congo
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Open AccessMarsh-orchids of Canada: long-standing mysteries partially solved
Between 1959 and 1988, three populations of purple-flowered terrestrial orchids attributable to Dactylorhiza subgenus Dactylorhiza were discovered in Canada. The populations at Timmins, Ontario, and St John's, Ne...
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Open AccessSynthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and Leishmania. The corresponding diseases have afflicted humans for centuries. In an effort t...
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Conjugation in polysiloxane copolymers via unexpected Si-O-Si dπ-pπ overlap, a second mechanism?
We previously reported that functionalized phenyl- and vinyl-silsesquioxanes (SQs) and [RSiO1.5]8,10,12 (R = Ph or vinyl) exhibited redshifted absorption and emission, suggesting 3-D conjugation via a cage-center...
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Open AccessRelationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
The aim of this study was to examine the dose–response associations of device-measured physical activity types and postures (sitting and standing time) with cardiometabolic health.
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Open AccessThe impact of expanded access programs for systemic anticancer therapy in an Irish cancer centre
Expanded access programs (EAPs) allow cancer patients with unmet clinical need to obtain access to pre-authorisation treatments. There is no standardised process for implementing these programs nationally, and...
