1,267 Result(s)
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Richard M. **
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Article
Open AccessA randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults
In preparation for mass vaccinations with R21/Matrix-M™ combined with mass administrations of dihydroartemisinin, piperaquine, and a single low dose primaquine we assessed the tolerability, safety, and potenti...
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Open AccessAndrogen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy
Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the vast majority (80–90...
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Open AccessMolecular ontogeny underlies the benefit of adding venetoclax to hypomethylating agents in newly diagnosed AML patients
The clinical impact of molecular ontogeny in acute myeloid leukemia (AML) was defined in patients treated with intensive chemotherapy. In a cohort of 314 newly diagnosed AML patients, we evaluated whether mole...
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Open AccessFunction estimation: Quantifying individual differences of hand-drawn functions
Graphical perception is an important part of the scientific endeavour, and the interpretation of graphical information is increasingly important among educated consumers of popular media, who are often present...
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Open Access3D architecture and complex behavior along the simple central San Andreas fault
The central San Andreas Fault (CSAF) exhibits a simple linear large-scale fault geometry, yet seismic and aseismic deformation features vary in a complex way along the fault. Here we investigate fault zone beh...
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Open AccessFrequency and Severity of Hypoglycemia Under Conditions of Increased Hypoglycemic Risk with Insulin Efsitora Alfa Versus Insulin Glargine Treatment in Participants with Type 2 Diabetes
Insulin efsitora alfa (efsitora) is a basal insulin with a flat pharmacokinetic profile and long half-life, enabling weekly dosing. These attributes may provide stable glucose levels. This exploratory phase 1 ...
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Open AccessThe single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of th...
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Open AccessMarsh-orchids of Canada: long-standing mysteries partially solved
Between 1959 and 1988, three populations of purple-flowered terrestrial orchids attributable to Dactylorhiza subgenus Dactylorhiza were discovered in Canada. The populations at Timmins, Ontario, and St John's, Ne...
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Open AccessSynthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and Leishmania. The corresponding diseases have afflicted humans for centuries. In an effort t...
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Open AccessRelationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
The aim of this study was to examine the dose–response associations of device-measured physical activity types and postures (sitting and standing time) with cardiometabolic health.
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Open AccessThe impact of expanded access programs for systemic anticancer therapy in an Irish cancer centre
Expanded access programs (EAPs) allow cancer patients with unmet clinical need to obtain access to pre-authorisation treatments. There is no standardised process for implementing these programs nationally, and...
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Open AccessConvergence Rates and Fluctuations for the Stokes–Brinkman Equations as Homogenization Limit in Perforated Domains
We study the homogenization of the Dirichlet problem for the Stokes equations in \(\mathbb {R}^3\) ...
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Open AccessRecommendations for reporting tissue and circulating tumour (ct)DNA next-generation sequencing results in non-small cell lung cancer
Non-small cell lung cancer is a heterogeneous disease and molecular characterisation plays an important role in its clinical management. Next-generation sequencing-based panel testing enables many molecular al...
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Open AccessPopulation pharmacokinetic modelling of primaquine exposures in lactating women and breastfed infants
Current guidelines advise against primaquine treatment for breastfeeding mothers to avoid the potential for haemolysis in infants with G6PD deficiency. To predict the haemolytic risk, the amount of drug receiv...
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Open AccessOn the Fire Hose Kickback Force in Solid Water Streams
This study investigates the kickback force (FK) experienced by firefighters during fire suppression using hoses of varying diameters and different nozzle sizes. Rigorous ground tests were conducted, where a fire ...
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Open AccessThe PARTNER trial of neoadjuvant olaparib with chemotherapy in triple-negative breast cancer
PARTNER is a prospective, phase II–III, randomized controlled clinical trial that recruited patients with triple-negative breast cancer1,2, who were germline BRCA1 and BRCA2 wild type3. Here we report the results...
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Open AccessIdentifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endome...
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Open AccessActivation of the native PHYTOENE SYNTHASE 1 promoter by modifying near-miss cis-acting elements induces carotenoid biosynthesis in embryogenic rice callus
Modification of silent latent endosperm-enabled promoters (SLEEPERs) allows the ectopic activation of non-expressed metabolic genes in rice callus
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Open AccessVisualizing chaperone-mediated multistep assembly of the human 20S proteasome
Dedicated assembly factors orchestrate the stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP) that mediates protein degradation. Here we report cryo-electron...
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Open AccessCurrent and projected flood exposure for Alaska coastal communities
Globally, coastal communities experience flood hazards that are projected to worsen from climate change and sea level rise. The 100-year floodplain or record flood are commonly used to identify risk areas for ...
