724 Result(s)
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Richard M. **
Life Sciences
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Article
Validation of a molecular sex marker in three sturgeons from eastern North America
Despite the importance of sex-specific information for sturgeon conservation and management, sex identification has been a major challenge outside of mature adults on spawning grounds. Recent work identified a...
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Article
Ants vs crabs: competition over seeds on a tropical island ecosystem
Seed dispersal by ants plays a major role globally in plant dynamics for many angiosperms and can be influenced by multiple factors. One of those factors is competition between ants and other organisms for gai...
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Article
Open AccessMarsh-orchids of Canada: long-standing mysteries partially solved
Between 1959 and 1988, three populations of purple-flowered terrestrial orchids attributable to Dactylorhiza subgenus Dactylorhiza were discovered in Canada. The populations at Timmins, Ontario, and St John's, Ne...
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Article
Open AccessActivation of the native PHYTOENE SYNTHASE 1 promoter by modifying near-miss cis-acting elements induces carotenoid biosynthesis in embryogenic rice callus
Modification of silent latent endosperm-enabled promoters (SLEEPERs) allows the ectopic activation of non-expressed metabolic genes in rice callus
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Article
Open AccessVisualizing chaperone-mediated multistep assembly of the human 20S proteasome
Dedicated assembly factors orchestrate the stepwise production of many molecular machines, including the 28-subunit proteasome core particle (CP) that mediates protein degradation. Here we report cryo-electron...
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Article
Mechanism of autocatalytic activation during proteasome assembly
Many large molecular machines are too elaborate to assemble spontaneously and are built through ordered pathways orchestrated by dedicated chaperones. During assembly of the core particle (CP) of the proteasom...
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Article
Open AccessSeven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
In rheumatoid arthritis (RA), the activation of T and B cell clones specific for self-antigens leads to the chronic inflammation of the synovium. Here, we perform an in-depth quantitative analysis of the seven...
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Article
Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains
A key aspect of nutrient absorption is the exquisite division of labour across the length of the small intestine, with individual nutrients taken up at different proximal:distal positions. For millennia, the s...
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Open AccessDetermining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study
Cellular senescence may be associated with morphological changes in skeletal muscle and changes in physical function with age although there have been few human studies. We aimed to determine the feasibility o...
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Protocol
Cancer Modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)
Transgenic expression of genes is a mainstay of cancer modeling in zebrafish. Traditional transgenic techniques rely upon injection into one-cell embryos, but ideally these transgenes would be expressed only i...
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Article
Enhancing the taxonomic delimitation of Lippia origanoides Kunth (Verbenaceae) by analyzing volatile terpenes and molecular markers in micropropagated accessions
This study aimed to contribute to the accurate taxonomic delimitation of Lippia origanoides Kunth (Verbenaceae), an important native Brazilian herb with diverse medicinal properties, culinary uses and wide phenot...
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Article
Open AccessExamination of head versus body heading may help clarify the extent to which animal movement pathways are structured by environmental cues?
Understanding the processes that determine how animals allocate time to space is a major challenge, although it is acknowledged that summed animal movement pathways over time must define space-time use. The cr...
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Article
Open AccessThe accumulation and growth of Pseudomonas aeruginosa on surfaces is modulated by surface mechanics via cyclic-di-GMP signaling
Attachment of bacteria onto a surface, consequent signaling, and accumulation and growth of the surface-bound bacterial population are key initial steps in the formation of pathogenic biofilms. While recent re...
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Article
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis
Assembly of the proteasome’s core particle (CP), a barrel-shaped chamber of four stacked rings, requires five chaperones and five subunit propeptides. Fusion of two half-CP precursors yields a complete structu...
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Article
Open AccessThe cost of inadequate postharvest management of pulse grain: Farmer losses due to handling and storage practices in Uganda
Investing in postharvest technologies is one way of reducing food losses with the aim of achieving food security, but it is often overlooked. In this study, we assessed the losses and costs associated with the...
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Article
Open AccessAsparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response
Robust and effective T cell immune surveillance and cancer immunotherapy require proper allocation of metabolic resources to sustain energetically costly processes, including growth and cytokine production. He...
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Article
Spider mite resistant maize lines, B75 and B96, maintain resistance under water-stress
Climate variability has major implications for agriculture due to the increase in the frequency and intensity of simultaneous abiotic, namely water-stress, and biotic stresses to crops. Plant water-stress alon...
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Article
Open AccessSystematic reappraisal of marsh-orchids native to Scotland
The intensively studied Eurasian orchid genus Dactylorhiza has become a model system for exploring allopolyploid evolution, yet determining the optimal circumscriptions of, and most appropriate ranks for, its con...
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Article
Quinolone: a versatile therapeutic compound class
The discovery of nalidixic acid is one pinnacle in medicinal chemistry, which opened a new area of research that has led to the discovery of several life-saving antimicrobial agents (generally referred to as f...
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Article
Open AccessEffects of simulated fire and browsing on the resprouting of subtropical dune thicket shrubs in the southeastern Cape Floristic Region
The expansion of subtropical thicket vegetation at the expense of more species-rich, fire-prone fynbos, potentially due to lower frequency and severity of fire and browsing, is a concern in many coastal dune l...
