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  1. Article

    Open Access

    Differences and similarities between cancer and somatic stem cells: therapeutic implications

    Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments. De...

    Fiorella Rossi, Hunter Noren, Richard Jove… in Stem Cell Research & Therapy (2020)

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    Article

    In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

    Tumors generate microenvironments that actively suppress the body's anti-tumor immune response. Kortylewski et al. restore immunity by delivering an siRNA against Stat3, a regulator of immune suppression, to myel...

    Marcin Kortylewski, Piotr Swiderski, Andreas Herrmann, Lin Wang… in Nature Biotechnology (2009)

  3. No Access

    Chapter

    STAT Proteins as Molecular Targets for Cancer Therapy

    Constitutive activation of the STAT family members, Stat3 and Stat5, occurs at very high frequency in diverse human cancers. Persistent STAT signaling in tumor cells has been shown to increase the expression o...

    Ralf Buettner, Marcin Kortylewski… in Signal Transducers and Activators of Trans… (2003)

  4. No Access

    Chapter

    Inhibition of Neurofibromin and p120 GTPASE Activating Protein (GAP) by Dietary Fatty Acids

    Neurofibromin and p120 GTPase activating protein (p120 GAP) down-regulate the activity of cellular Ras proteins. How the activity of these two proteins is controlled is not yet clear. In this study, we analyze...

    Joung H. Lee, Jyoti A. Harwalkar… in Eicosanoids and Other Bioactive Lipids in … (1999)