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  1. Article

    Open Access

    Comparison of robot-assisted versus fluoroscopy-guided transforaminal lumbar interbody fusion (TLIF) for lumbar degenerative diseases: a systematic review and meta-analysis of randomized controlled trails and cohort studies

    As an emerging technology in robot-assisted (RA) surgery, the potential benefits of its application in transforaminal lumbar interbody fusion (TLIF) lack substantial support from current evidence.

    Jianbin Guan, Ningning Feng, **ng Yu, Kaitan Yang in Systematic Reviews (2024)

  2. Article

    Open Access

    The effectiveness of e-mental health interventions on stress, anxiety, and depression among healthcare professionals: a systematic review and meta-analysis

    Many healthcare professionals are experiencing psychological distress. Electronic mental health (e-mental health) interventions are convenient and multifunctional. This review aimed to examine the effectivenes...

    Zemiao Zhang, Yinhuan Hu, Sha Liu, **andong Feng, **hong Yang in Systematic Reviews (2024)

  3. Article

    Open Access

    4-Aminopyridine treatment for nerve injury resulting from radical retro-pubic prostatectomy: a single-center double-blind, randomized, placebo-controlled study

    Prostate cancer (PCa) is the most common non-cutaneous malignancy in men and leads to the second most common cause of cancer related mortality in men. Early detection of PCa allows for a potentially curative i...

    Ahmed Ghazi, Thomas L. Osinski, Changyong Feng, Andrea Horne, John Elfar in Trials (2024)

  4. Article

    Open Access

    Gamma oscillations induced by 40-Hz visual-auditory stimulation for the treatment of acute-phase limb motor rehabilitation after stroke: study protocol for a prospective randomized controlled trial

    The incidence of hemiparetic limb dysfunction reaches 85% in stroke patients, emerging as a critical factor influencing their daily lives. However, the effectiveness of current rehabilitation treatments is con...

    Wang Fu, **aoming Yu, Minghui Lai, Yuanli Li, Yingting Yang, Yong Qin, Min Yu in Trials (2024)

  5. Article

    Open Access

    Effects of task-based mirror therapy on upper limb motor function in hemiplegia: study protocol for a randomized controlled clinical trial

    Research to date has lacked definitive evidence to determine whether mirror therapy promotes the recovery of upper extremity function after stroke. Considering that previous studies did not stratify patients b...

    Hongzhen Liu, Yangjie Xu, Wei Jiang, Fangchao Hu, Yi Zhou, Lu Pan, Feng Zhou in Trials (2024)

  6. Article

    Open Access

    Effectiveness of WeChat-assisted preoperative education to reduce perioperative anxiety in breast cancer patients: a prospective randomized controlled study protocol

    Breast cancer is the most prevalent cancer among women globally, and surgical procedures continue to be the primary treatment. However, over 50% of patients experience preoperative anxiety due to the unknown a...

    **ao **ao, Yi-Ding Zuo, Shu-Yu Kuang, Chun-Yuan Liu, Kun-Shao, Heng Wang in Trials (2024)

  7. Article

    Open Access

    Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study)

    The increasing prevalence of childhood obesity has become an urgent public health problem, evidence showed that intervention for childhood obesity bring enormous health benefits. However, an effective individu...

    **-** Zhang, You-xin Wang, Fang-**g Shen, Yun-fei **ng, Jia-ying Gu in Trials (2024)

  8. Article

    Open Access

    Suicide prevention for substance using youth experiencing homelessness: study protocol for a randomized controlled trial

    While research on substance using youth experiencing homelessness (YEH) is increasing, there is a dearth of information regarding effective prevention interventions for these youth. Suicide is the leading caus...

    Natasha Slesnick, Brittany Brakenhoff, Laura J. Chavez, Caleb L. Cuthbertson in Trials (2024)

  9. Article

    Open Access

    Effectiveness and brain mechanism of multi-target transcranial alternating current stimulation (tACS) on motor learning in stroke patients: study protocol for a randomized controlled trial

    Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on th...

    Ming-Hui Lai, **ao-Ming Yu, Yan Lu, Hong-Lin Wang, Wang Fu, Huan-**a Zhou in Trials (2024)

  10. Article

    Open Access

    Efficacy of ultrasound-guided erector spinae plane block on analgesia and quality of recovery after minimally invasive direct coronary artery bypass surgery: protocol for a randomized controlled trial

    Minimally invasive direct coronary artery bypass (MIDCAB) surgery offers an effective option for coronary artery disease (CAD) patients with the avoidance of median sternotomy and fast postoperative recovery. ...

    Ling **n, Lu Wang, Yi Feng in Trials (2024)

  11. Article

    Open Access

    A nitrous oxide/oxygen fixed mixture to reduce pain induced by the hypodermic injection: study protocol for a randomized, controlled trial

    Patients with hematological malignancies received multiple hypodermic injections of recombinant human granulocyte colony-stimulating factor. Procedural pain is one of the most common iatrogenic causes of pain ...

    Jun-Jun Zhang, ** Yu, Hui Dang, Cheng-Shuang Feng, **u-Jiang Long, Wen-Fa Huang in Trials (2024)

  12. Article

    Open Access

    Effect of transvaginal Lactobacillus supplementation on reversing lower genital tract dysbiosis and improving perinatal outcomes in PCOS patients after IVF-FET: a study protocol for a multicenter randomized controlled trial

    Significant lower genital tract (LGT) dysbiosis and an associated lower rate of clinical pregnancy after in vitro fertilization–frozen embryo transfer (IVF-FET) among polycystic ovary syndrome (PCOS) patients ...

    Huixi Chen, Yaoyao Tu, Chen Zhang, Jie Li, Ting Wu, Suying Liu, Liying He in Trials (2023)

  13. Article

    Open Access

    Quality of reporting of integrative Chinese and Western medicine intervention in randomized controlled trials of ulcerative colitis: a review

    Integrative Chinese and Western medicine (ICWM) is commonly used for the treatment of ulcerative colitis (UC) in clinical practice. However, it is unclear whether the details of ICWM interventions, such as sel...

    Jialing Zhang, Jiashuai Deng, Nana Wang, ** Wang, Ji Li in Systematic Reviews (2023)

  14. Article

    Open Access

    REVISE: re-evaluating the inhibition of stress erosions in the ICU—statistical analysis plan for a randomized trial

    The REVISE (Re-Evaluating the Inhibition of Stress Erosions in the ICU) trial will evaluate the impact of the proton pump inhibitor pantoprazole compared to placebo in invasively ventilated critically ill patient...

    Diane Heels-Ansdell, Laurent Billot, Lehana Thabane, Waleed Alhazzani, Adam Deane in Trials (2023)

  15. Article

    Open Access

    Effect of the telemedicine-supported multicomponent exercise therapy in patients with knee osteoarthritis: study protocol for a randomized controlled trial

    The rising prevalence of knee osteoarthritis is placing a considerable strain on the global healthcare system. To address this issue, telemedicine-supported multicomponent exercise therapy has emerged as a pro...

    Yuan Feng, Yan Wu, Huizhen Liu, Tianjie Bao, Chongyang Wang, Zezhang Wang in Trials (2023)

  16. Article

    Open Access

    Comparison of different weight-based scalars of remimazolam tosylate for anesthesia induction in obese patients: study protocol for a prospective, controlled trial

    The physiologic and anthropometric characteristics changes associated with obesity may result in the alternation of pharmacologic management. Remimazolam tosylate is a new type of ultra-short-acting benzodiaze...

    Wenwen Ni, **uwen Yi, Lili Feng, Yilei Shen, Jiali Jiao, Yirong Cai, Danyun Fu in Trials (2023)

  17. Article

    Open Access

    Effects of proprioceptive training on gait and plantar pressure after anterior cruciate ligament reconstruction: study protocol for a randomized controlled trial

    People who have undergone anterior cruciate ligament reconstruction have an increased risk of osteoarthritis. Abnormality of lower limb kinematics will occur after the operation. This may be related to lower l...

    Zhao **aojun, Ma Ming, Guo Jianye, Sun Wudong, Qu Yi, Cui Jun, Huang Ningqinq in Trials (2023)

  18. Article

    Open Access

    Comparing the effectiveness of extracorporeal shockwave therapy and myofascial release therapy in chronic pelvic pain syndrome: study protocol for a randomized controlled trial

    Chronic prostatitis/chronic pelvic pain syndrome is a highly prevalent syndrome. Previous studies showed that extracorporeal shockwave therapy and myofascial release therapy could improve the quality of life i...

    Ningqing Huang, Zhi Qin, Wudong Sun, Kaiming Bao, **gxian Zha, Peng Zhang in Trials (2023)

  19. Article

    Open Access

    Dual tracer navigation for lymph node dissection in laparoscopic radical gastrectomy (DANCE trial): a protocol for a prospective, randomized clinical trial

    Lymph node (LN) metastasis is the most common metastasis route in gastric cancer. Extensive dissection of LNs can significantly improve the prognosis of patients with gastric cancer. Recently, multiple clinica...

    Yanjun Lu, Shichao Ai, Peng Song, Yan Sun, **aofei Shen, Feng Sun, Qiongyuan Hu in Trials (2023)

  20. Article

    Open Access

    Effectiveness of neuromuscular electrical stimulation in severe acute pancreatitis complicated patients with acute respiratory distress syndrome: study protocol for a randomized controlled trial

    Severe acute pancreatitis complicated by acute respiratory distress is a common cause of intensive care unit (ICU) admission. These patients are at risk of a decline in physical activity due to bed rest. Neuro...

    Feng Zhou, Dingrong Fan, Yan Feng, Cuijuan Zhou, **aodong Chen, **aoyun Ran in Trials (2023)

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