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Article
Open AccessDeletion of all three MAP kinase genes results in severe defects in stress responses and pathogenesis in Fusarium graminearum
Mitogen-activated protein kinase (MAPK) cascades are activated by external stimuli and convert signals to cellular changes. Individual MAPKs have been characterized in a number of plant pathogenic fungi for th...
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Article
A single-cell transcriptomic landscape of the lungs of patients with COVID-19
The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19)-related mortality. However, our ...
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Article
Plant multiscale networks: charting plant connectivity by multi-level analysis and imaging techniques
In multicellular and even single-celled organisms, individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis f...
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Article
Open AccessA cohort autopsy study defines COVID-19 systemic pathogenesis
Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied by dysfunction of the lungs and extrapulmonary organs. However, the organotropism of SARS-CoV-2 and the port of virus entry for systemic d...
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Article
Modulation of the immune response and metabolism in germ-free rats colonized by the probiotic Lactobacillus salivarius LI01
The gut microbiota plays an important role in multifaceted physiological functions in the host. Previous studies have assessed the probiotic effects of Lactobacillus salivarius LI01. In this study, we aimed to in...
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Article
Lactobacillus salivarius LI01 encapsulated in alginate-pectin microgels ameliorates d-galactosamine-induced acute liver injury in rats
Acute liver failure is a clinical emergency associated with high mortality. Accumulating evidence indicates that gut microbiota participates in the progression of liver injury, and preventive therapies based o...
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Article
Open AccessLINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression
The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows th...
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Article
Comparative transcriptomic analysis of resistant and susceptible tea cultivars in response to Empoasca onukii (Matsuda) damage
Transcriptomic studies in resistant and susceptible tea cultivars have been performed to reveal the different defense molecular mechanisms of tea after E. onukii feeding.
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Article
Lactobacillus helveticus R0052 alleviates liver injury by modulating gut microbiome and metabolome in d-galactosamine-treated rats
The liver is an important digestive gland, and acute liver failure results in high mortality. Probiotics are considered potential adjuvant therapies for liver disease. This study aimed to investigate the benef...
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Article
Bifidobacterium adolescentis CGMCC 15058 alleviates liver injury, enhances the intestinal barrier and modifies the gut microbiota in d-galactosamine-treated rats
Acute liver failure is a drastic, unpredictable clinical syndrome with high mortality. Various preventive and adjuvant therapies based on modulating the gut flora have been proposed for hepatic injury. We aime...
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Article
HBeAg induces the expression of macrophage miR-155 to accelerate liver injury via promoting production of inflammatory cytokines
Activation of Kupffer cells (KCs) induced that inflammatory cytokine production plays a central role in the pathogenesis of HBV infection. The previous studies from our and other laboratory demonstrated miRNAs...
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Article
Characterization of a novel micro-pressure swirl reactor for removal of chemical oxygen demand and total nitrogen from domestic wastewater at low temperature
A novel micro-pressure swirl reactor (MPSR) was designed and applied to treat domestic wastewater at low temperature by acclimating microbial biomass with steadily decreasing temperature from 15 to 3 °C. Chem...
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Article
Synergistic Interactions Between Salt-tolerant Rhizobia and Arbuscular Mycorrhizal Fungi on Salinity Tolerance of Sesbania cannabina Plants
Legumes can host rhizobia and mycorrhizal fungi, and this triple symbiosis might be exploited to improve saline soil fertility. Therefore, a greater understanding of the interaction of rhizobia and arbuscular ...