132 Result(s)
within
Ren-**ng Song
Life Sciences
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Article
Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice
Nutritional status and pyroptosis are important for host defence against infections. However, the molecular link that integrates nutrient sensing into pyroptosis during microbial infection is unclear. Here, us...
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Open AccessSimultaneous determination of five plant hormones in cotton leaves using QuEChERS combined with HPLC‒MS/MS
Plant hormones profoundly influence cotton growth, development, and responses to various stresses. Therefore, there is a pressing need for an efficient assay to quantify these hormones in cotton. In this groun...
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Article
Open AccessFBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression
FBXO32, a member of the F-box protein family, is known to play both oncogenic and tumor-suppressive roles in different cancers. However, the functions and the molecular mechanisms regulated by FBXO32 in lung a...
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Open AccessAberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60 years of age worldwide, the incidence of prostate diseases, such...
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Open AccessLactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...
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Open AccessA small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at the clinical level. ...
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Open Access3α-Hydroxybufadienolides in Bufo gallbladders: structural insights and biotransformation
Bufadienolides, naturally occurring steroids primarily found in toads, have garnered attention for their pharmacological properties and ecological significance. In this study, we isolated and identified 21 buf...
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Legacy effects of preceding crops improve flue-cured tobacco productivity in southwest China by optimizing soil structure, nutrients, and microbial interactions
The use of legume crops and garlic as preceding crops has positive effects on soil quality and crop yield. However, little is known about how preceding crops optimize and regulate the interactions among soil m...
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Weak responses of soil microorganisms to leaf litter inputs after native Phyllostachys edulis invasion into adjacent native forests
Moso bamboo (Phyllostachys pubescens) invasions into native forest cause a series of ecological problems, including the alteration of soil microorganism community composition. Additionally, it has been establishe...
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Open AccessUnraveling the 2,3-diketo-l-gulonic acid-dependent and -independent impacts of l-ascorbic acid on somatic cell reprogramming
l-ascorbic acid (Asc) plays a pivotal role in regulating various biological processes, including somatic cell reprogramming, through multiple pathways. However, it remains unclear whether Asc regulates reprogra.....
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Open AccessThe Quartet Data Portal: integration of community-wide resources for multiomics quality control
The Quartet Data Portal facilitates community access to well-characterized reference materials, reference datasets, and related resources established based on a family of four individuals with identical twins ...
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Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination
Human spermatogenesis is a highly ordered process; however, the roles of DNA methylation and chromatin accessibility in this process remain largely unknown. Here by simultaneously investigating the chromatin a...
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Soil nitrate mediates the responses of plant community production to the frequency of N addition in a temperate grassland: a decadal field experiment
Nitrogen (N) enrichment through either artificial N application or atmospheric N deposition often increases ecosystem aboveground net primary productivity (ANPP). Therefore, results from N addition experiments...
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Responses of soil carbon cycling microbial functional genes to nitrogen and phosphorus addition in saline-sodic soils
Nitrogen (N) and phosphorus (P) have important roles in the terrestrial carbon (C) cycle. Nevertheless, the responses of microbial ecological functions involving C cycling in saline-sodic soils to N and P are ...
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Article
Multiple domestications of Asian rice
The origin of domesticated Asian rice (Oryza sativa L.) has been controversial for more than half a century. The debates have focused on two leading hypotheses: a single domestication event in China or multiple d...
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Article
YTHDF2 negatively correlates with tumor immune infiltration in small cell lung cancer
In recent times, RNA modifications have garnered increased attention due to their involvement in the onset and progression of tumors, with N6-methyladenosine (m6A) modification being the most prevalent form. Y...
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Open AccessAkkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum
Periodontitis is the most important cause of tooth loss in adults and is closely related to various systemic diseases. Its etiologic factor is plaque biofilm, and the primary treatment modality is plaque contr...
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GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis
Nonalcoholic fatty liver disease (NAFLD) is characterised by hepatic steatosis, inflammation, and insulin resistance. The role of long noncoding RNA (lncRNA)-regulated pyroptosis in NAFLD development remains l...
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Optimizing human endometrial mesenchymal stem cells for maximal induction of angiogenesis
Human endometrial mesenchymal stem cells (hEMSCs) have been shown to promote neo-vascularization; however, its angiogenic function lessens with age. To determine the optimal conditions for maximizing hEMSC ang...
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Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
