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Chapter
ω3 and ω6 Essential Fatty Acid Status in Human Health and Disease
In 1943 when I began research with Professor George O. Burr on the chemistry of essential fatty acids (EFA), there were no methods to measure individual fatty acids (FA) in tissue lipids. Using the new Beckman...
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Article
Diets rich in lean beef increase arachidonic acid and long-chain ω3 polyunsaturated fatty acid levels in plasma phospholipids
Diets rich in meat are claimed to contribute to the high tissue arachidonic acid (20∶4ω6) content in people in Westernized societies, but there are very few direct data to substantiate this assertion. Because ...
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Article
Essential fatty acid deficient rats fed hydrogenated oil —A response
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Article
Reduced adipose 18∶3ω3 with weight loss by very low calorie dieting
The human undergoing rapid and sustained weight loss by very low calorie dieting (VLCD) derives the majority of daily energy needs from adipose fatty acids. To evaluate the rates of metabolic utilization of in...
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Article
Collisional activation of a series of homoconjugated octadecadienoic acids with fast atom bombardment and tandem mass spectrometry
High-energy collisional activation (CA) of long-chain fatty acid ions induces decompositions that occur remote from the charge site. These charge-remote fragmentations (CRFs) have been shown to provide much st...
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Article
Fatty acid pattern of tissue phospholipids in copper and iron deficiencies
Because copper and iron have been reported to be essential cofactors in Δ9 desaturation of fatty acids, the effects of different dietary intakes of copper and iron on tissue fatty acids were studied. Male Long...
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Article
Effects of Biotin Deficiency on Plasma and Tissue Fatty Acid Composition: Evidence for Abnormalities in Rats
ABSTRACT: Abnormalities of fatty acid composition have been detected in the plasma of patients who developed frank biotin deficiency during parenteral nutrition. We sought to determine which abnormalities of f...
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Article
Polyunsaturated fatty acids of serum lipids in myocardial infarction
Two groups of volunteers had blood drawn for serum analysis of fatty acids. The first group was comprised of patients admitted to the hospital with possible myocardial infarction (MI). Blood was drawn at admis...
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Article
Efficacy of linoleic acid administered rectally as monoglyceride
The potential of the rectal route for administration of essential fatty acids (EFA) as monoglyceride (MG) was investigated. EFA-deficient rats were supplemented with 14 mg linoleic acid/day for 3 days. Supplem...
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Chapter
Conditions Influencing Essentiality of Polyunsaturated Fatty Acids
The polyunsaturated fatty acids were shown to have special nutritional value in studies by Burr and Burr, who found that dietary fats contain an essential growth-promoting factor not due to fat-soluble vitamin...
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Article
A comparison of pyrrolidide and picolinyl ester derivatives for the identification of fatty acids in natural samples by gas chromatography-mass spectrometry
The pyrrolidide and picolinyl ester derivatives of the fatty acids in two natural lipid samples rich in unsaturated fatty acids, pig testis lipids and cod liver oil were satisfactorily resolved on capillary co...
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Article
Editorial
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Article
Dietary fats containing concentrates ofcis ortrans octadecenoates and the patterns of polyunsaturated fatty acids of liver phosphatidylcholine and phosphatidylethanolamine
The effects of the mixedcis- 18∶1 isomers and mixedtrans-18∶1 isomers present in partially hydrogenated soybean oil (PHSO) upon the patterns of polyunsaturated fatty acids (PUFA) in liver phosphatidylcholine (PC)...
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Article
How essential are essential fatty acids?
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Article
Mass spectrometric identification of C20 fatty acids bovine lens using the pyrrolidide derivative
Unsaturated C20 fatty acids from bovine lens have been examined via gas chromatography-mass spectrometry of their pyrrolidine derivatives. The presence of arachidonic acid and 5,8,11-20∶3 in bovine lens has been ...
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Article
Committee Spotlights
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Article
ESSENTIAL FATTY ACID (EFA) DEFICIENCY IN NEONATES: INABILITY TO REVERSE DEFICIENCY BY TOPICAL APPLICATION OF EFA-RICH OIL
Successful treatment of EFA deficiency by topical application of an EFA-rich oil has been reported. To further define efficacy of the topical route, serum EFA levels were measured in 10 neonates receiving fat-...
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Chapter
Essential Fatty Acids in Human Nutrition
Half a century ago, George and Mildred Burr were beginning their studies on the effects of a fat-free diet upon rats (Burr and Burr 1929, 1930). Since that time, the story of essential fatty acids (EFA) has pr...
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Article
Mass spectrometric localization of methyl branching in fatty acids using acylpyrrolidines
Localization of a methyl branch in a fatty acid molecule by mass spectrometry is facilitated by using the pyrrolidide rather than the methyl ester. Branched fatty acid methyl esters are converted to pyrrolidid...
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Article
Mass spectrometric determination of positions of double bonds in polyunsaturated fatty acid pyrrolidides
Low resolution mass spectra of pyrrolidides of isomeric octadecadienoic acids and other polyunsaturated straight chain fatty acids are presented and discussed. The spectra of the pyrrolidides contain mainly io...
