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Article

Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8⁺ T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. O...

Antje Sucker, Fang Zhao, Natalia Pieper, Christina Heeke… in Nature Communications (2017)