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    Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results

    Adoptive cell transfer (ACT) with neoantigen-reactive T lymphocytes can mediate cancer regression. Here we isolated unique, personalized, neoantigen-reactive T cell receptors (TCRs) from tumor-infiltrating lym...

    Maria Parkhurst, Stephanie L. Goff, Frank J. Lowery, Rachel K. Beyer… in Nature Medicine (2024)