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Article
Trace aluminum determination and sampling problems of archeological bone employing destructive neutron activation analysis
A destructive neutron activation analysis procedure was developed for determining trace aluminum content in bone. It was found that soil contamination can influence the aluninum bone levels in prehistoric bone...
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Article
Fracture risk as determined by prospective and retrospective study designs
Both retrospectively and prospectively designed studies consistently show low bone mass and/or bone mineral content (BMC) to be risk factor for low-trauma fractures in postmenopausal women. Along with the repo...
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Article
Prevention of osteoporosis: Calcium nutrition
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Article
Revisable criteria for vertebral deformity
In order to study vertebral fractures in various study populations, we earlier prepared a database of vertebral dimensions derived from spinal radiographs of 191 normal women seen regularly over 25 years. In t...
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Article
On animal models for studying bone adaptation
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Article
Mechanical loading stimulates rapid changes in periosteal gene expression
Although mechanical forces regulate bone mass and morphology, little is known about the signals involved in that regulation. External force application increases periosteal bone formation by increasing surface...
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Article
Ultrasound, densitometry, and extraskeletal appendicular fracture risk factors: A cross-sectional report on The Saunders County Bone Quality Study
The Saunders County Bone Quality Study was designed to determine the feasibility of ultrasonic bone measurement, at the patella, as a predictor of low-trauma fractures in a runal population-based study. At the...
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Article
How biased are odds ratios that are determined from redalled fracture histories?
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Article
Bone histomorphometry in long-term studies of alendronate in postmenopausal osteoporosis
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Article
Prevalence and severity of vertebral fracture: The saunders county bone quality study
Vertebral fracture prevalence and severity were analyzed by sex and age in an age-stratified proportionate sample of the enumerated population of women and men 50 years of age and older in Saunders County, Neb...
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Article
Caffeine does not affect the rate of gain in spine bone in young women
The effect of nutrition and dietary caffeine consumption and physical activity on bone gain in women during the third decade of life was determined in a longitudinal, descriptive study of 145 healthy college-a...
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Article
Influence of Activity Level on Patellar Ultrasound Transmission Velocity in Children
Optimum development of both bone mass and bone quality during childhood is crucial in prevention of osteoporosis, a condition in which fractures occur late in life. Increasing physical activity is one modalit...
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Article
Bone Response to In Vivo Mechanical Loading in Two Breeds of Mice
We investigated the bone response to external loading in C57BL/6J and C3H/HeJ mice, both breeds with low and high bone density, respectively. An in vivo tibial four-point bending device previously used for appli...
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Article
Urinary Calcium in Perimenopausal Women: Normative Values
Twenty-four hour urinary calcium was measured under controlled dietary and metabolic balance conditions in 191 normal perimenopausal women at 5-year intervals, under varying conditions of estrogen status and ...
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Article
The Association of Bone Mineral Density with Vitamin D Receptor Gene Polymorphisms
A recent meta-analysis of 16 publications suggested that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP) at the 0.05 significance level when a study with g...
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Article
Association of VDR and Estrogen Receptor Genotypes with Bone Mass in Postmenopausal Caucasian Women: Different Conclusions with Different Analyses and the Implications
Much work has been done on the association between vitamin D receptor (VDR) genotypes and bone mineral density (BMD). Despite considerable effort, the results are inconsistent. While the VDR association remai...
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Article
Bone Response to In Vivo Mechanical Loading in C3H/HeJ Mice
Bone, being sensitive to mechanical stimulus, adapts to mechanical loads in response to bending or deformation. Although the signal/receptor mechanism for bone adaptation to deformation is still under investi...
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Article
Therapeutic equivalence of alendronate 70 mg onceweekly and alendronate 10 mg daily in the treatment of osteoporosis
Dosing convenience is a key element in the effective management of any chronic disease, and is particularly important in the long-term management of osteoporosis. Less frequent dosing with any medication may e...
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Article
Study Subjects and Ordinary Patients
Clinical trials of treatment agents impose strict and often necessary inclusion and exclusion criteria, while patients presenting to physicians for treatment frequently exhibit complicating features that woul...
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Article
Genetic Variations in Bone Density, Histomorphometry, and Strength in Mice
The purpose of this study was to assess breed-related differences in bone histomorphometry, bone biomechanics, and serum biochemistry in three mouse breeds shown to differ in bone mineral density (BMD) (as me...
