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    Article

    On animal models for studying bone adaptation

    C. H. Turner, M. R. Forwood, D. M. Raab-Cullen in Calcified Tissue International (1994)

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    Article

    Mechanical loading stimulates rapid changes in periosteal gene expression

    Although mechanical forces regulate bone mass and morphology, little is known about the signals involved in that regulation. External force application increases periosteal bone formation by increasing surface...

    D. M. Raab-Cullen, M. A. Thiede, D. N. Petersen in Calcified Tissue International (1994)

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    Article

    Ultrasound, densitometry, and extraskeletal appendicular fracture risk factors: A cross-sectional report on The Saunders County Bone Quality Study

    The Saunders County Bone Quality Study was designed to determine the feasibility of ultrasonic bone measurement, at the patella, as a predictor of low-trauma fractures in a runal population-based study. At the...

    D. Travers-Gustafson, M. R. Stegman, R. P. Heaney in Calcified Tissue International (1995)

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    Article

    Bone Response to In Vivo Mechanical Loading in Two Breeds of Mice

    We investigated the bone response to external loading in C57BL/6J and C3H/HeJ mice, both breeds with low and high bone density, respectively. An in vivo tibial four-point bending device previously used for appli...

    M. P. Akhter, D. M. Cullen, E. A. Pedersen, D. B. Kimmel in Calcified Tissue International (1998)

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    Article

    Bone Response to In Vivo Mechanical Loading in C3H/HeJ Mice

    Bone, being sensitive to mechanical stimulus, adapts to mechanical loads in response to bending or deformation. Although the signal/receptor mechanism for bone adaptation to deformation is still under investi...

    E. A. Pedersen, M. P. Akhter, D. M. Cullen, D. B. Kimmel in Calcified Tissue International (1999)

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    Article

    Genetic Variations in Bone Density, Histomorphometry, and Strength in Mice

    The purpose of this study was to assess breed-related differences in bone histomorphometry, bone biomechanics, and serum biochemistry in three mouse breeds shown to differ in bone mineral density (BMD) (as me...

    M. P. Akhter, U. T. Iwaniec, M. A. Covey, D. M. Cullen in Calcified Tissue International (2000)

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    Article

    A Second-Stage Genome Scan for QTLs Influencing BMD Variation

    Low bone mineral density (BMD) is a major risk factor for osteoporotic fracture. To identify genomic regions harboring quantitative trait loci (QTLs) contributing to BMD variation, we performed a two-stage gen...

    Q. -Y. Huang, F. -H. Xu, H. Shen, L. -J. Zhao in Calcified Tissue International (2004)

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    Article

    Genetic and Environmental Correlations of Bone Mineral Density at Different Skeletal Sites in Females and Males

    Bone mineral density (BMD) is a complex trait having genetic and environmental determination. There are gender-specific differences in BMD measurements, and the rate of BMD changes with age and lifestyle. Prev...

    T.-L. Yang, L.-J. Zhao, Y.-J. Liu, J.-F. Liu in Calcified Tissue International (2006)

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    Article

    Daily Treatment of Aged Ovariectomized Rats with Human Parathyroid Hormone (1-84) for 12 Months Reverses Bone Loss and Enhances Trabecular and Cortical Bone Strength

    Most studies that have investigated the anabolic effects of parathyroid hormone (1-84) (PTH) or PTH fragments on the skeleton of ovariectomized (OVX) rats have evaluated the short-term effects of high-dose PTH...

    J. Fox, M. A. Miller, M. K. Newman, A. F. Metcalfe in Calcified Tissue International (2006)

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    Article

    Effects of Treatment of Ovariectomized Adult Rhesus Monkeys with Parathyroid Hormone 1-84 for 16 Months on Trabecular and Cortical Bone Structure and Biomechanical Properties of the Proximal Femur

    Treatment of monkeys and humans with parathyroid hormone (PTH) 1-84 stimulates skeletal remodeling, which increases trabecular (Tb) bone mineral density (BMD) but decreases cortical (Ct) BMD at locations where...

    J. Fox, M. A. Miller, R. R. Recker, C. H. Turner in Calcified Tissue International (2007)

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    Article

    Relationship of Bone Mineralization Density Distribution (BMDD) in Cortical and Cancellous Bone Within the Iliac Crest of Healthy Premenopausal Women

    Bone mineralization density distribution (BMDD) is an important determinant of bone mechanical properties. The most available skeletal site for access to the BMDD is the iliac crest. Compared to cancellous bo...

    B. M. Misof, D. W. Dempster, Hua Zhou, P. Roschger in Calcified Tissue International (2014)

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    Article

    Effect of Macroanatomic Bone Type and Estrogen Loss on Osteocyte Lacunar Properties in Healthy Adult Women

    This is the first study to examine clinical human bone specimens by three-dimensional imaging to characterize osteocyte lacunar properties as a function of macroanatomic bone type and estrogen loss. We applied...

    Mohammed P. Akhter, D. B. Kimmel, J. M. Lappe in Calcified Tissue International (2017)