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Open AccessAre higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?
To explore the association between antidepressant plasma concentrations and fall risk in older users.
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Open AccessIn silico evaluation of limited sampling strategies for individualized dosing of extended half-life factor IX concentrates in hemophilia B patients
Hemophilia B is a bleeding disorder, caused by a factor IX (FIX) deficiency. Recently, FIX concentrates with extended half-life (EHL) have become available. Prophylactic dosing of EHL-FIX concentrates can be o...
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Open AccessPhase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks
To determine the maximum-tolerated dose (MTD), dose-limiting toxicities, and pharmacokinetics of topotecan administered as a 30-min intravenous (i.v.) infusion over 5 days in combination with a 1-h i.v. infusi...