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    Pharmacokinetic-pharmacodynamic modelling in pre-clinical investigations: principles and perspectives

    A new approach to preclinical pharmacodynamic investigations is presented which allows, in addition to information on the nature of the pharmacological properties of new chemical entities, also important quant...

    M. Danhof, J. W. Mandema, A. Hoogerkamp… in European Journal of Drug Metabolism and Ph… (1993)