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Article

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction properties and in their bioact...

C Tiveron, L Fasulo, S Capsoni, F Malerba, S Marinelli… in Cell Death & Differentiation (2013)