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  1. No Access

    Article

    Association of p53 gene alterations with the expression of antiapoptotic survivin splice variants in breast cancer

    Survivin, a member of the inhibitory apoptosis protein family, gives rise, by an alternative splicing, to four variants with different functions. Many experimental studies indicate that p53 can regulate the expre...

    F Végran, R Boidot, C Oudin, C Defrain, M Rebucci, S Lizard-Nacol in Oncogene (2007)

  2. No Access

    Article

    The transcription factor GATA-1 is overexpressed in breast carcinomas and contributes to survivin upregulation via a promoter polymorphism

    Expression of survivin, a member of the inhibitor of apoptosis protein family, is elevated in human cancers and considered as a new therapeutic target. Mechanism upregulating survivin expression in tumour cell...

    R Boidot, F Végran, D Jacob, S Chevrier, M Cadouot, O Feron, E Solary… in Oncogene (2010)

  3. No Access

    Article

    A new ER-specific photosensitizer unravels 1O2-driven protein oxidation and inhibition of deubiquitinases as a generic mechanism for cancer PDT

    Photosensitizers (PS) are ideally devoid of any activity in the absence of photoactivation, and rely on molecular oxygen for the formation of singlet oxygen (1O2) to produce cellular damage. Off-targets and tumor...

    A Pinto, Y Mace, F Drouet, E Bony, R Boidot, N Draoui, I Lobysheva, C Corbet… in Oncogene (2016)