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Open AccessTumour hypoxia determines the potential of combining mTOR and autophagy inhibitors to treat mammary tumours
Hypoxia can activate autophagy, a self-digest adaptive process that maintains cell turnover. Mammalian target of rapamycin (mTOR) inhibitors are used to treat cancer but also stimulate autophagy.
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Article
Open AccessGene expression profile and response to trastuzumab–docetaxel-based treatment in breast carcinoma
Resistance to trastuzumab is often observed in women with human epidermal growth factor receptor 2 (HER2)-positive breast cancer and has been shown to involve multiple potential mechanisms. We examined the abi...