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Article
Open AccessA specific super-enhancer actuated by berberine regulates EGFR-mediated RAS–RAF1–MEK1/2–ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy
Nasopharyngeal carcinoma (NPC), primarily found in the southern region of China, is a malignant tumor known for its highly metastatic characteristics. The high mortality rates caused by the distant metastasis ...
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Article
Open AccessJUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis
Oncogenic super-enhancers (SEs) generate noncoding enhancer/SE RNAs (eRNAs/seRNAs) that exert a critical function in malignancy through powerful regulation of target gene expression. Herein, we show that a JUN...
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Article
Open AccessA novel oncogenic seRNA promotes nasopharyngeal carcinoma metastasis
Nasopharyngeal carcinoma (NPC) is a common malignant cancer in southern China that has highly invasive and metastatic features and causes high mortality, but the underlying mechanisms of this malignancy remain...
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Article
Open AccessOncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms
Super-enhancers (SEs) consist of a cluster of many enhancers bound to a great number of transcription factors. They are critical cis-regulatory elements that determine the identity of various human cell types....
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Article
Open AccessSelf-assembled HCV core virus-like particles targeted and inhibited tumor cell migration and invasion
We used a baculovirus expression system to express fusion proteins of HCV core, RGD (Arg-Gly-Asp) peptide, and IFN-α2a fragments in Sf9 cells. Western blotting and electron microscopy demonstrate that HCV core...
