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Article
Open AccessDifferential networking meta-analysis of gastric cancer across Asian and American racial groups
Gastric Carcinoma is one of the most lethal cancer around the world, and is also the most common cancers in Eastern Asia. A lot of differentially expressed genes have been detected as being associated with Gas...
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Article
Open AccessDRAP: a toolbox for drug response analysis and visualization tailored for preclinical drug testing on patient-derived xenograft models
One of the key reasons for the high failure rate of new agents and low therapeutic benefit of approved treatments is the lack of preclinical models that mirror the biology of human tumors. At present, the opti...
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Article
Open AccessA conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
Zinc finger protein X-linked (ZFX) has been shown to promote the growth of tumor cells, including leukemic cells. However, the role of ZFX in the growth and drug response of chronic myeloid leukemia (CML) stem...
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Article
Open AccessmiR-181a plays the tumor-suppressor role in chronic myeloid leukemia CD34 + cells partially via SERPINE1
The formation of the BCR-ABL fusion gene drives human chronic myeloid leukemia (CML). The last 2 decades have witnessed that specific tyrosine kinase inhibitors (TKIs, e.g., imatinib mesylate, IM) against ABL1 im...
