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Article
Open AccessRedefining and interpreting genomic relationships of metafounders
Metafounders are a useful concept to characterize relationships within and across populations, and to help genetic evaluations because they help modelling the means and variances of unknown base population ani...
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Article
Open AccessEstimating genomic relationships of metafounders across and within breeds using maximum likelihood, pseudo-expectation–maximization maximum likelihood and increase of relationships
The theory of “metafounders” proposes a unified framework for relationships across base populations within breeds (e.g. unknown parent groups), and base populations across breeds (crosses) together with a sens...
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Article
Open AccessGenomic evaluation for two-way crossbred performance in cattle
Dairy cattle production systems are mostly based on purebreds, but recently the use of crossbreeding has received increased interest. For genetic evaluations including crossbreds, several methods based on sing...
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Article
Open AccessAnti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study
Ardisia gigantifolia Stapf. (AGS), a Chinese folk medicine widely grows in the south of China and several studies reported that AGS could inhibit the proliferation of breast cancer, liver cancer, and bladder can...
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Article
Open AccessImpacts of additive, dominance, and inbreeding depression effects on genomic evaluation by combining two SNP chips in Canadian Yorkshire pigs bred in China
At the beginning of genomic selection, some Chinese companies genotyped pigs with different single nucleotide polymorphism (SNP) arrays. The obtained genomic data are then combined and to do this, several impu...
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Article
Mechanical stretching of 3D hydrogels for neural stem cell differentiation
While it is known that mechanical dynamics are influential in neural differentiation for critical processes like neurogenesis or neurodegeneration, studies on neural stem cell therapies usually focus on bioche...
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Article
Open AccessSmall extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in regenerative medicine. MenSC has received increasing attention owing to its impressive therapeutic effects in both preclinical an...
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Article
Open AccessGenome-wide association and transcriptome studies identify candidate genes and pathways for feed conversion ratio in pigs
The feed conversion ratio (FCR) is an important productive trait that greatly affects profits in the pig industry. Elucidating the genetic mechanisms underpinning FCR may promote more efficient improvement of ...
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Article
Open AccessChimeric antigen receptor (CAR)-T-cell therapy in non-small-cell lung cancer (NSCLC): current status and future perspectives
There has been a rapid progress in develo** genetically engineered T cells in recent years both in basic and clinical cancer studies. Chimeric antigen receptor (CAR)-T cells exert an immune response against ...
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Article
Open AccessChemical reaction kinetics and the characteristic properties of injectable adhesives of nano-hydroxyapatite/Ag3PO4/polyurethane for bone and tooth repair
Advancements have been made to injectable polymer technologies following the development of minimally invasive techniques for bone and tooth treatment. To improve the conversion rate and avoid potential toxici...
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Article
Triterpenoids from the Roots and Stems of Rubus alceaefolius
A phytochemical investigation of the roots and stems of Rubus alceaefolius Poir. let to the isolation of two oleanane-type triterpenoids, 2α,3α-dihydroxyolean-11,13(18)-dien-19β,28-olide ...
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Article
Mechanical characterization of cervical squamous carcinoma cells by atomic force microscopy at nanoscale
To investigate the nanoscale mechanical properties of exfoliated cervical epithelial cells from patients to further reveal the pathogenesis of cervical cancer and help early diagnose. Exfoliated cells were col...
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Article
Open AccessComparisons of Contact Chemoreception and Food Acceptance by Larvae of Polyphagous Helicoverpa armigera and Oligophagous Bombyx mori
We compared food choice and the initial response to deterrent treated diet between fifth instars of Helicoverpa armigera, a polyphagous generalist pest, and Bombyx mori, an oligophagous specialist beneficial. Bom...
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Article
Construction and identification of a yeast two-hybrid bait vector and its effect on the growth of yeast cells and the self-activating function of reporter genes for screening of HPV18 E6-interacting protein
By using a yeast two-hybrid system, a yeast two-hybrid bait vector was constructed and identified for screening of the HPV18 E6-interacting proteins, and its effects on the growth of yeast cells and the activa...
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Article
Magnetic resonance evaluation of transplanted endometrial carcinoma and its lymph node metastasis in rabbits
To establish a rabbit model of transplanted endometrial carcinoma with lymph node metastasis and observe its magnetic resonance imaging (MRI) features.
