30 Result(s)

Article

Characterization of the intestinal microbiota in MSM with HIV infection

HIV-infected persons demonstrate notable disturbances in their intestinal microbiota; however, the impact of intestinal microbiota on HIV susceptibility in men who have sex with men (MSM), as well as the effec...

Yuansheng Fu, Susu Ke, Gan Tang, Qisheng Guo, Qian Guo, Ziwei Wang… in BMC Microbiology (2024)

Article

DDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis

Acute kidney injury (AKI) constitutes a prevalent clinical syndrome characterized by elevated morbidity and mortality rates, emerging as a significant public health issue. This study investigates the interplay...

Haijiao **, Yuanting Yang, Xuying Zhu, Yin Zhou, Yao Xu, Jialin Li… in Cell Death & Disease (2024)

Article

HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome

Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal fibrosis remains unclear...

Jialin Li, Qisheng Lin, **nghua Shao, Shu Li, Xuying Zhu… in Cell Death & Disease (2023)

Article

The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer

The activity of integrin-linked kinase (ILK) in cancerous cells is often oncogenic and associated with malignant properties, such as uncontrolled cell cycle progression and evasion from senescence. However, th...

Chengbo Ji, Mili Zhang, Junjie Hu, Can Cao, Qisheng Gu, Youdong Liu… in Cell Death & Disease (2022)

Article

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

Jun Lan, **nheng He, Yifei Ren, Ziyi Wang, Huan Zhou, Shilong Fan… in Cell Research (2022)

Article

Genome of the parasitoid wasp Cotesia chilonis sheds light on amino acid resource exploitation

A fundamental feature of parasitism is the nutritional exploitation of host organisms by their parasites. Parasitoid wasps lay eggs on arthropod hosts, exploiting them for nutrition to support larval developme...

**nhai Ye, Shijiao **ong, Ziwen Teng, Yi Yang, Jiale Wang, Kaili Yu… in BMC Biology (2022)

Article

Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health worldwide, the development of effective interventions is urgently needed. Neutralizing antibodies (nAbs) ...

Yongbing Pan, Jianhui Du, Jia Liu, Hai Wu, Fang Gui, Nan Zhang… in Cell Discovery (2021)

Article

Structure of SARS-CoV-2 main protease in the apo state

Xuelan Zhou, Fanglin Zhong, Cheng Lin, **aohui Hu, Yan Zhang… in Science China Life Sciences (2021)

Article

20E-mediated regulation of BmKr-h1 by BmKRP promotes oocyte maturation

Krüppel homolog 1 (Kr-h1) is a critical transcription factor for juvenile hormone (JH) signaling, known to play a key role in regulating metamorphosis and adult reproduction in insects. Kr-h1 can also be induc...

Zidan Zhu, Chunmei Tong, Binbin Qiu, Hongguang Yang, Jiahui Xu, Sichun Zheng… in BMC Biology (2021)

Article

Genome-wide analysis of DNA G-quadruplex motifs across 37 species provides insights into G4 evolution

G-quadruplex (G4) structures have been predicted in the genomes of many organisms and proven to play regulatory roles in diverse cellular activities. However, there is little information on the evolutionary hi...

Feng Wu, Kangkang Niu, Yong Cui, Cencen Li, Mo Lyu, Yandong Ren… in Communications Biology (2021)

Article

Broad-complex transcription factor mediates opposing hormonal regulation of two phylogenetically distant arginine kinase genes in Tribolium castaneum

The phosphoarginine-arginine kinase shuttle system plays a critical role in maintaining insect cellular energy homeostasis. Insect molting and metamorphosis are coordinated by fluctuations of the ecdysteroid a...

Nan Zhang, Heng Jiang, **angkun Meng, Kun Qian, Ya** Liu… in Communications Biology (2020)

Article

Genome-wide identification and comparison of differentially expressed profiles of miRNAs and lncRNAs with associated ceRNA networks in the gonads of Chinese soft-shelled turtle, Pelodiscus sinensis

The gonad is the major factor affecting animal reproduction. The regulatory mechanism of the expression of protein-coding genes involved in reproduction still remains to be elucidated. Increasing evidence has ...

**ao Ma, Shuangshuang Cen, Luming Wang, Chao Zhang, Limin Wu, Xue Tian… in BMC Genomics (2020)

Article

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury

Contrast-induced acute kidney injury (CI-AKI) is a serious complication in patients after administration of iodinated contrast media and is associated with a significant high risk for severe renal failure and ...

Zhen Zhang, **nghua Shao, Na Jiang, Shan Mou, Leyi Gu, Shu Li… in Cell Death & Disease (2018)

Article

Interaction of the primordial germ cell-specific protein C2EIP with PTCH2 directs differentiation of embryonic stem cells via HH signaling activation

Although many marker genes for germ cell differentiation have been identified, genes that specifically regulate primordial germ cell (PGC) generation are more difficult to determine. In the current study, we c...

Qisheng Zuo, Kai **, Jiuzhou Song, Yani Zhang, Guohong Chen… in Cell Death & Disease (2018)

Article

MicroRNA-125b-5p suppresses Brucella abortus intracellular survival via control of A20 expression

Brucella may establish chronic infection by regulating the expression of miRNAs. However, the role of miRNAs in modulating the intracellular growth of Brucella remains unclear.

Ning Liu, Lin Wang, Changjiang Sun, Li Yang, Wanchun Sun, Qisheng Peng in BMC Microbiology (2016)

Article

Review of source identification methodologies for heavy metals in solid waste

Source characterization of heavy metals is prerequisite to assessing their potential contamination pathways and environmental risks, based on which pollution control and environmental remediation measures can ...

Hua Zhang, QiSheng Yao, YuMin Zhu, ShiSuo Fan, Pin**g He in Chinese Science Bulletin (2013)

Article

Changes in global potential vegetation distributions from 1911 to 2000 as simulated by the Comprehensive Sequential Classification System approach

Vegetation classification models play an important role in studying the response of the terrestrial ecosystem to global climate change. In this paper, we study changes in global Potential Natural Vegetation (P...

TianGang Liang, QiSheng Feng, JianJun Cao, HongJie **e… in Chinese Science Bulletin (2012)